Communication between the brain and peripheral mediators of systemic inflammation is implicated in numerous psychological, behavioral, and physiological processes. Functional neuroimaging studies have identified brain regions that associate with peripheral inflammation in humans, yet there are open questions about the consistency, specificity, and network characteristics of these findings. The present systematic review provides a meta-analysis to address these questions. Multilevel kernel density analysis of 24 studies (37 statistical maps; 264 coordinates; 457 participants) revealed consistent effects in the amygdala, hippocampus, hypothalamus, striatum, insula, midbrain, and brainstem, as well as prefrontal and temporal cortices. Effects in some regions were specific to particular study designs and tasks. Spatial pattern analysis revealed significant overlap of reported effects with limbic, default mode, ventral attention, and corticostriatal networks, and co-activation analyses revealed functional ensembles encompassing the prefrontal cortex, insula, and midbrain/brainstem. Together, these results characterize brain regions and networks associated with peripheral inflammation in humans, and they provide a functional neuroanatomical reference point for future neuroimaging studies on brain-body interactions.

大脑与全身性炎症的外周介质之间的交流与许多心理，行为和生理过程有关。功能性神经影像学研究已经确定了与人类周围发炎相关的大脑区域，但是关于这些发现的一致性，特异性和网络特征仍存在悬而未决的问题。本系统综述提供了荟萃分析来解决这些问题。对24项研究的多级内核密度分析（37个统计图； 264个坐标； 457个参与者）显示，杏仁核，海马，下丘脑，纹状体，岛状，中脑和脑干以及额叶和颞叶皮层具有一致的作用。在某些地区的效果是特定于特定研究设计和任务的。空间模式分析显示，所报告的作用与边缘，默认模式，腹侧注意和皮质造口网显着重叠，共同激活分析显示功能性集合体包括前额叶皮层，岛突和中脑/脑干。总之，这些结果表征了与人类外周炎症相关的大脑区域和网络，并且它们为将来对脑-机体相互作用的神经影像学研究提供了功能性的神经解剖学参考点。