Gold(I)‐catalyzed Benzylation of (Hetero)aryl Boronic Acids with (Hetero)benzyl Bromides by the Strategy of a SN2‐type Reaction,Chemistry - An Asian Journal

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Gold(I)‐catalyzed Benzylation of (Hetero)aryl Boronic Acids with (Hetero)benzyl Bromides by the Strategy of a SN2‐type Reaction
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2018-08-31 , DOI: 10.1002/asia.201800923
Wenqing Zang ₁ , Yin Wei ₁ , Min Shi ₁

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Herein, the first example of gold‐catalyzed benzylation of (hetero)aryl boronic acids with (hetero)benzyl bromides to give the corresponding cross‐coupling products in moderate to good yields is reported. The reaction proceeds through a possible intermolecular S_N2‐type reaction pathway to give a wide variety of di(hetero)arylmethanes as the desired products. An intriguing reaction mechanism has been proposed on the basis of control experiments, ³¹P‐NMR spectroscopic detection and DFT calculations.

中文翻译：

金（I）催化的（杂）苄基溴与（杂）苄基溴的SN2型反应策略

在此，报道了第一个用（杂）苄基溴对（杂）芳基硼酸进行金催化的苄基化反应，以得到中等至良好收率的相应交叉偶联产物的实例。反应通过可能的分子间S _N 2型反应路径进行，从而得到各种所需的二（杂）芳基甲烷。在控制实验，³¹ P-NMR光谱检测和DFT计算的基础上，提出了一种有趣的反应机理。

更新日期：2018-08-31

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