Sequential double C–H functionalization of 2,5-norbornadiene in flow†,Reaction Chemistry & Engineering

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Sequential double C–H functionalization of 2,5-norbornadiene in flow†
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2018-07-27 00:00:00 , DOI: 10.1039/c8re00131f
Heejin Kim _{1,

2,

3,

4,

5} , Zuoyufan Yin _{2,

5,

6,

7,

8} , Hidehiro Sakurai _{2,

5,

6,

7,

8} , Jun-ichi Yoshida _{1,

2,

3,

4,

5}

Affiliation

An anionic species of 2,5-norbornadiene was generated and brominated using a flow reactor. In the second step, 2-bromo-2,5-norbornadiene was lithiated with LTMP and reacted with tributyltin chloride. Finally, an integrated one-flow synthesis using various electrophiles was achieved within 3 min to prepare 2-bromo-2,5-norbornadienes bearing a functional group at the 3-position.

中文翻译：

流动中2,5-降冰片二烯的连续双CH功能化†

生成2,5-降冰片二烯的阴离子物质，并使用流动反应器将其溴化。在第二步中，将2-溴-2,5-降冰片二烯与LTMP锂化，并与三丁基氯化锡反应。最后，在3分钟内完成了使用各种亲电试剂的一体化单流合成反应，以制备在3位带有官能团的2-溴-2,5-降冰片二烯。

更新日期：2018-07-27

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