Recent Advances in Metal-Catalyzed Asymmetric 1,4-Conjugate Addition (ACA) of Nonorganometallic Nucleophiles,Chemical Reviews

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Recent Advances in Metal-Catalyzed Asymmetric 1,4-Conjugate Addition (ACA) of Nonorganometallic Nucleophiles
Chemical Reviews ( IF 51.4 ) Pub Date : 2018-07-26 00:00:00 , DOI: 10.1021/acs.chemrev.7b00692
Ke Zheng ₁ , Xiaohua Liu ₁ , Xiaoming Feng ₁

Affiliation

The metal-catalyzed asymmetric conjugate addition (ACA) reaction has emerged as a general and powerful approach for the construction of optically active compounds and is among the most significant and useful reactions in synthetic organic chemistry. In recent years, great progress has been made in this area with the use of various chiral metal complexes based on different chiral ligands. This review provides comprehensive and critical information on the enantioselective 1,4-conjugate addition of nonorganometallic (soft) nucleophiles and their importance in synthetic applications. The literature is covered from the last 10 years, and a number of examples from before 2007 are included as background information. The review is divided into multiple parts according to the type of nucleophile involved in the reaction (such as C-, B-, O-, N-, S-, P-, and Si-centered nucleophiles) and metal catalyst systems used.

中文翻译：

非有机金属亲核试剂的金属催化不对称1,4-共轭加成反应（ACA）的最新进展

金属催化的不对称共轭加成（ACA）反应已成为构建光学活性化合物的通用且有效的方法，并且是合成有机化学中最重要和最有用的反应之一。近年来，通过使用基于不同手性配体的各种手性金属配合物，在该领域已取得了很大的进步。这篇综述提供了有关非有机金属（软）亲核试剂的对映选择性1,4-共轭加成及其在合成应用中的重要性的全面和关键的信息。文献涵盖了过去10年，并包含了2007年之前的许多示例作为背景信息。根据反应涉及的亲核试剂的类型（例如C-，B-，O-，N-，S-，P-，

更新日期：2018-07-26

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