Stimuli-responsive polymer materials are powerful tools in drug delivery and tissue engineering. Because of the large variations in physiological conditions between normal microenvironments and diseased sites, polymer materials with single responsiveness may not achieve the desired goals in a complex physiological microenvironment. Instead, polymer materials responsive to multiple physical or chemical stimuli are highly desired for biomedical applications (e.g., drug delivery). In this review, we highlight recent studies in multi-stimuli-responsive materials with a specific emphasis on polymer particles, films, and hydrogels. The synthetic strategies employed to produce these responsive materials are described. Applications in drug delivery are highlighted, followed by a discussion of the current research focus and future trends.

刺激响应性高分子材料是药物输送和组织工程中的有力工具。由于正常微环境和患病部位之间的生理状况差异很大，因此具有单一响应能力的聚合物材料可能无法在复杂的生理微环境中达到所需的目标。取而代之的是，对于生物医学应用（例如，药物递送），非常需要对多种物理或化学刺激有响应的聚合物材料。在这篇综述中，我们重点介绍了对多刺激反应性材料的最新研究，特别是对聚合物颗粒，薄膜和水凝胶的研究。描述了用于生产这些响应性材料的合成策略。重点介绍了药物输送中的应用，然后讨论了当前的研究重点和未来趋势。