TBAI/TBHP‐Promoted Generation of Malonyl Radicals: Oxidative Coupling with Styrenes Leads to γ‐Keto Diesters,Chemistry - An Asian Journal

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TBAI/TBHP‐Promoted Generation of Malonyl Radicals: Oxidative Coupling with Styrenes Leads to γ‐Keto Diesters
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2018-08-30 , DOI: 10.1002/asia.201800992
Soumyadeep Roy Chowdhury ₁ , Injamam Ul Hoque ₁ , Soumitra Maity ₁

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A metal‐free protocol for oxidative coupling of malonic esters with styrenes to form γ‐keto diesters has been developed. Key to the success of this process is the generation of malonyl radicals from unfunctionalized malonic esters under organo‐catalysis conditions with TBAI and TBHP. This process tolerates both terminal and internal olefins with diverse malonic esters. It provides a new green metal‐free alternative to traditional metal mediated process for generation of malonyl radicals and there by γ‐keto diesters.

中文翻译：

TBAI / TBHP促进丙二酸自由基的生成：与苯乙烯的氧化偶联导致生成γ-酮基二酯

已开发出一种无金属的方案，用于丙二酸酯与苯乙烯的氧化偶合以形成γ-酮二酯。该工艺成功的关键是在有机催化条件下，利用TBAI和TBHP，由未官能化的丙二酸酯生成丙二酰基。该方法耐受各种丙二酸酯的末端和内部烯烃。它提供了一种新的绿色无金属替代品，可替代传统的金属介导的方法来生成丙二酸基自由基，并通过γ-酮二酯在此生成丙二酸自由基。

更新日期：2018-08-30

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