Different schemes were studied for the recovery of wastes generated during the industrial production of isosorbide-5-mononitrate (IS-5-MN). For the wastewater, disposal was achieved by hydrolysis of isosorbide-2-mononitrate (IS-2-MN) to the starting material isosorbide (IS) utilizing its alkaline environment, where NaOAc was also recovered effectively in the form of the trihydrate. For the solid waste, two different schemes were investigated: direct crystallization and catalytic hydrogenation. The former afforded useful isosorbide dinitrate (ISDN) efficiently, and the latter provided an efficient and scalable route to synthesize IS-5-MN from ISDN. The combinations of unit operations were evaluated on a 100 kg scale and proved to be feasible and robust. The waste recycling strategy provides an eco-friendly complement for the industrial-scale preparation of IS-5-MN, which minimizes waste emission during the process.

中文翻译：

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一种工业生产5-一硝酸异山梨酯的改进工艺：废物回收

研究了不同的方案以回收工业生产5一硝酸异山梨酯（IS-5-MN）中产生的废物。对于废水，通过利用其碱性环境将异山梨醇-2-一硝酸酯（IS-2-MN）水解为原料异山梨醇（IS）来实现处置，其中NaOAc也以三水合物的形式有效地回收了。对于固体废物，研究了两种不同的方案：直接结晶和催化氢化。前者有效地提供了有用的硝酸异山梨酯（ISDN），而后者则提供了一种有效且可扩展的路线，可以从ISDN合成IS-5-MN。单位操作的组合以100千克规模进行了评估，并被证明是可行且可靠的。