Searching for prospective agents against infectious diseases, four new ferrocenyl derivatives, [M(L)(dppf)4](PF₆), with M = Pd(II) or Pt(II), dppf = 1,1′-bis(dipheny1phosphino) ferrocene and HL = tropolone (HTrop) or hinokitiol (HHino), were synthesized and characterized. Complexes and ligands were evaluated against the bloodstream form of T. brucei, L. infantum amastigotes, M. tuberculosis (MTB) sensitive strain and MTB clinical isolates. Complexes showed a significant increase of the anti-T. brucei activity with respect to the free ligands (>28- and >46-fold for Trop and 6- and 22-fold for Hino coordinated to Pt-dppf and Pd-dppf, respectively), yielding IC₅₀ values < 5 μM. The complexes proved to be more potent than the antitrypanosomal drug Nifurtimox. The new ferrocenyl derivatives were more selective towards the parasite than the free ligands. The Pt compounds were less toxic on J774 murine macrophages (mammalian cell model), than the Pd ones, showing selectivity index values (SI = IC₅₀ murine macrophage/IC₅₀ T. brucei) up to 23. Generation of the {M-dppf} compounds lead to a slightly positive impact on the anti-leishmanial potency. Although the ferrocenyl derivatives were more active on sensitive MTB than the free ligands (MIC₉₀ = 9.88–14.73 μM), they showed low selectivity towards the pathogen. Related to the mechanism of action, the antiparasitic effect cannot be ascribed to an interference of the compounds with the thiol-redox homeostasis of the pathogen. Fluorescence measurements pointed at DNA as a probable target of the new compounds. [Pt(Trop)(dppf)](PF₆) and [Pt(Hino)(dppf)](PF₆) could be considered prospective anti-T. brucei agents that deserve further research.

寻找抗传染病的前瞻性药物，四种新的二茂铁基衍生物[M（L）（dppf）4]（PF ₆），其中M = Pd（II）或Pt（II），dppf = 1,1'-bis（合成并表征了二苯基膦基二茂铁和HL =对苯二酚（HTrop）或扁柏酚（HHino）。复合物和配体对的血流形式进行评价布氏锥虫，婴儿利什曼原虫的无鞭毛体，结核分枝杆菌（MTB）敏感菌株和MTB临床分离株。相对于游离配体，复合物显示出抗布鲁氏杆菌的活性显着提高（分别与Pt-dppf和Pd-dppf配位的Trop的> 28-和> 46倍，Hino的6-和22-倍） ），产生IC ₅₀值<5μM。事实证明，该复合物比抗锥虫药Nifurtimox更有效。新的二茂铁基衍生物对寄生虫的选择性高于游离配体。Pt化合物对J774鼠巨噬细胞（哺乳动物细胞模型）的毒性小于Pd化合物，显示高达23的选择性指数值（SI = IC ₅₀鼠巨噬细胞/ IC ₅₀ T. brucei）。 }化合物对抗leishmanial效力产生积极影响。尽管二茂铁基衍生物在敏感MTB上比游离配体更具活性（MIC ₉₀ = 9.88–14.73μM），对病原体的选择性低。与作用机理有关，抗寄生虫作用不能归因于化合物对病原体硫醇-氧化还原稳态的干扰。荧光测量结果表明DNA是新化合物的可能靶标。[Pt（Trop）（dppf）]（PF ₆）和[Pt（Hino）（dppf）]（PF ₆）被认为是前瞻性抗布鲁氏菌的药物，值得进一步研究。