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The Future of Bioorthogonal Chemistry
ACS Central Science ( IF 12.7 ) Pub Date : 2018-07-23 00:00:00 , DOI: 10.1021/acscentsci.8b00251 Neal K. Devaraj 1
ACS Central Science ( IF 12.7 ) Pub Date : 2018-07-23 00:00:00 , DOI: 10.1021/acscentsci.8b00251 Neal K. Devaraj 1
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Bioorthogonal reactions have found widespread use in applications ranging from glycan engineering to in vivo imaging. Researchers have devised numerous reactions that can be predictably performed in a biological setting. Depending on the requirements of the intended application, one or more reactions from the available toolkit can be readily deployed. As an increasing number of investigators explore and apply chemical reactions in living systems, it is clear that there are a myriad of ways in which the field may advance. This article presents an outlook on the future of bioorthogonal chemistry. I discuss currently emerging opportunities and speculate on how bioorthogonal reactions might be applied in research and translational settings. I also outline hurdles that must be cleared if progress toward these goals is to be made. Given the incredible past successes of bioorthogonal chemistry and the rapid pace of innovations in the field, the future is undoubtedly very bright.
中文翻译：
生物正交化学的未来
已经发现生物正交反应在从聚糖工程到体内成像的各种应用中得到广泛使用。研究人员设计了许多可以在生物环境中可预测地进行的反应。根据预期应用程序的需求，可以轻松部署可用工具包中的一个或多个响应。显然，随着越来越多的研究者探索和应用化学反应在生命系统中，很显然，该领域有许多发展的方式。本文介绍了生物正交化学的未来前景。我讨论了当前出现的机会，并推测了如何在研究和翻译环境中应用生物正交反应。我还概述了要实现这些目标必须克服的障碍。
更新日期：2018-07-23
中文翻译：
生物正交化学的未来
已经发现生物正交反应在从聚糖工程到体内成像的各种应用中得到广泛使用。研究人员设计了许多可以在生物环境中可预测地进行的反应。根据预期应用程序的需求，可以轻松部署可用工具包中的一个或多个响应。显然，随着越来越多的研究者探索和应用化学反应在生命系统中，很显然，该领域有许多发展的方式。本文介绍了生物正交化学的未来前景。我讨论了当前出现的机会，并推测了如何在研究和翻译环境中应用生物正交反应。我还概述了要实现这些目标必须克服的障碍。
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