Siderophores are chemically diverse small molecules produced by microorganisms for chelation of irons to maintain their survival and govern some important biological functions, especially those cause that infections in hosts. Still, siderophores can offer new insight into a better understanding of the diagnosis and treatments of infectious diseases from the siderophore biosynthesis and regulation perspective. Thus, this review aims to summarize the biomedical value and applicability of siderophores in pathogenic contexts by briefly reviewing mass spectrometry (MS)‐based chemical biology and translational applications that involve diagnosis, pathogenesis, and therapeutic discovery for a variety of infectious conditions caused by different pathogens. We highlight the advantages and disadvantages of siderophore discovery and applications in pathogenic contexts. Finally, we propose a panel of new and promising strategy as precision‐modification metabolomics method, to rapidly advance the discovery of and translational innovations pertaining to these value compounds in broad biomedical niches. © 2018 Wiley Periodicals, Inc. Mass Spec Rev XX:XX–XX, 2018.

中文翻译：

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质谱法和相关技术描述了在不同病原体环境下铁载体的有利生物医学能力。

铁载体是微生物产生的化学上多样的小分子，用于螯合铁以维持其生存并控制某些重要的生物学功能，尤其是那些导致宿主感染的功能。尽管如此，从铁载体生物合成和调控的角度来看，铁载体可以为更好地理解传染病的诊断和治疗提供新的见解。因此，本综述旨在通过简要回顾基于质谱（MS）的化学生物学和转化应用（涉及诊断，发病机制和治疗发现）的概述，来总结铁载体在致病性背景下的生物医学价值和适用性，病原体。我们重点介绍了铁载体的发现和在病原体环境中的应用的优缺点。最后，我们提出了一组新的且有希望的策略，作为精确修饰代谢组学方法，以快速推进广泛的生物医学领域中与这些价值化合物有关的发现和转化创新。©2018 Wiley Periodicals，Inc.质谱修订版XX：XX–XX，2018年。