Discovery of multi-drug resistant, MCR-1 and ESBL-coproducing ST117 Escherichia coli from diseased chickens in northeast China,Science Bulletin

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Discovery of multi-drug resistant, MCR-1 and ESBL-coproducing ST117 Escherichia coli from diseased chickens in northeast China
Science Bulletin ( IF 18.8 ) Pub Date : 2018-07-21 , DOI: 10.1016/j.scib.2018.07.017
Sijia Ding ₁ , Xiaohu Han ₂ , Jun Li ₃ , Weifan Gao ₂ , Zeliang Chen ₂ , Youjun Feng ₄

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An endemic multi-drug resistant ST117 E. coli isolate coproducing MCR-1 and 3 ESBL loci was, for the first time, detected from diseased chicken, Liaoning Province, in Northeast China, from 2011 to 2012. Whole-genome sequencing revealed 5 unique plasmids, namely pHXH-1, pHXH-2, pHXH-3, pHXH-4 and pHXH-5). Among them, pHXH1 and pHXH4 encode ESBL, and pHXH-5 mediates MCR-1 colistin resistance. The results indicate that the potentially-national dissemination of MCR-1-positive pathogens with pan-drug resistance proceeds via food chains.

更新日期：2018-07-21

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