During decidualization, human mesenchymal-like endometrial stromal cells undergo well characterized cellular and molecular transformations in preparation for accepting a developing embryo. Modulation of cellular biophysical properties during decidualization is likely to be important in receptivity and support of the embryo in the uterus. Here we assess the biophysical properties of human endometrial stromal cells including topography, roughness, adhesiveness and stiffness in cells undergoing in vitro decidualization. A significant reduction in cell stiffness and surface roughness was observed following decidualization. These morphodynamical changes have been shown to be associated with alterations in cellular behavior and homeostasis, suggesting that localized endometrial cell biophysical properties play a role in embryo implantation and pregnancy. This cell–cell communication process is thought to restrict trophoblast invasion beyond the endometrial stroma, be essential in the establishment of pregnancy, and demonstrate the altered endometrial dynamics affecting cell–cell contact and migration regimes at this crucial interface in human reproduction.

在蜕膜化过程中，人间充质样子宫内膜基质细胞会经历特征化的细胞和分子转化，以准备接受正在发育的胚胎。蜕膜化过程中细胞生物物理特性的调节可能对子宫内胚胎的接受和支持很重要。在这里，我们评估了人类子宫内膜间质细胞的生物物理特性，包括体外细胞的形貌，粗糙度，粘附性和刚度蜕皮化。蜕皮化后观察到细胞刚度和表面粗糙度显着降低。这些形态动力学变化已被证明与细胞行为和体内稳态的改变有关，表明局部子宫内膜细胞的生物物理特性在胚胎着床和妊娠中起作用。人们认为这种细胞与细胞的通讯过程限制了滋养层细胞侵入子宫内膜基质之外，这对妊娠的建立至关重要，并且证明了改变的子宫内膜动力学影响了人类生殖这一关键界面上的细胞与细胞的接触和迁移方式。