Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Toxic effects of zinc oxide nanoparticles combined with vitamin C and casein phosphopeptides on gastric epithelium cells and the intestinal absorption of mice†
RSC Advances ( IF 3.9 ) Pub Date : 2018-07-20 00:00:00 , DOI: 10.1039/c8ra03693d Tianjiao Gu 1 , Chenjie Yao 1 , Kangkang Zhang 1 , Chenchen Li 1 , Lin Ding 1 , Yanan Huang 1 , Minghong Wu 2 , Yanli Wang 1
RSC Advances ( IF 3.9 ) Pub Date : 2018-07-20 00:00:00 , DOI: 10.1039/c8ra03693d Tianjiao Gu 1 , Chenjie Yao 1 , Kangkang Zhang 1 , Chenchen Li 1 , Lin Ding 1 , Yanan Huang 1 , Minghong Wu 2 , Yanli Wang 1
Affiliation
|
Zinc oxide nanomaterials have become common food additives in recent years. Casein phosphopeptides (CPP) and vitamin C (VC) are used as functional food additives together with ZnO nanoparticles (ZnO NPs) in many commercial foods. Our previous studies showed that VC can increase the cytotoxicity induced by ZnO NPs both in vitro and in vivo, while CPP can have a cytoprotective effect against oxidative stress induced by ZnO NPs. However, the combined toxic effect of the three additives together in food is unknown. Herein, we have investigated the combined toxicity of ZnO NPs, CPP and VC by altering the sequence of their addition to clarify their toxic mechanisms in the composite systems. When the order of addition of the three materials changes, the cytotoxicity induced by the ZnO NPs changes due to the different concentrations of dissolved Zn ions in the different groups. We have also probed the intestinal absorption of Zn ions with an everted gut sac model. The amount of Zn2+ absorbed in the intestine in different composite systems also responds differently to the sequence of addition of the additives. VC is more powerful at controlling the synergistic toxic effect induced by ZnO NPs compared to the protective role of CPP in the combined systems.
中文翻译：
氧化锌纳米粒联合维生素C和酪蛋白磷酸肽对小鼠胃上皮细胞和肠道吸收的毒性作用†
近年来，氧化锌纳米材料已成为常见的食品添加剂。酪蛋白磷酸肽 (CPP) 和维生素 C (VC) 在许多商业食品中与 ZnO 纳米颗粒 (ZnO NPs) 一起用作功能性食品添加剂。我们之前的研究表明，VC 可以增加 ZnO NPs在体外和体内诱导的细胞毒性, 而 CPP 对 ZnO NPs 诱导的氧化应激具有细胞保护作用。然而，这三种添加剂在食品中的综合毒性作用尚不清楚。在此，我们通过改变它们的添加顺序来研究 ZnO NPs、CPP 和 VC 的组合毒性，以阐明它们在复合系统中的毒性机制。当三种材料的添加顺序发生变化时，由于不同组中溶解的Zn离子浓度不同，ZnO NPs诱导的细胞毒性也会发生变化。我们还用外翻的肠囊模型探测了肠道对锌离子的吸收。Zn 2+的量在不同的复合系统中被肠道吸收的物质对添加剂的添加顺序也有不同的反应。与 CPP 在组合系统中的保护作用相比，VC 在控制 ZnO NPs 诱导的协同毒性作用方面更强大。
更新日期：2018-07-20
中文翻译：
氧化锌纳米粒联合维生素C和酪蛋白磷酸肽对小鼠胃上皮细胞和肠道吸收的毒性作用†
近年来，氧化锌纳米材料已成为常见的食品添加剂。酪蛋白磷酸肽 (CPP) 和维生素 C (VC) 在许多商业食品中与 ZnO 纳米颗粒 (ZnO NPs) 一起用作功能性食品添加剂。我们之前的研究表明，VC 可以增加 ZnO NPs在体外和体内诱导的细胞毒性, 而 CPP 对 ZnO NPs 诱导的氧化应激具有细胞保护作用。然而，这三种添加剂在食品中的综合毒性作用尚不清楚。在此，我们通过改变它们的添加顺序来研究 ZnO NPs、CPP 和 VC 的组合毒性，以阐明它们在复合系统中的毒性机制。当三种材料的添加顺序发生变化时，由于不同组中溶解的Zn离子浓度不同，ZnO NPs诱导的细胞毒性也会发生变化。我们还用外翻的肠囊模型探测了肠道对锌离子的吸收。Zn 2+的量在不同的复合系统中被肠道吸收的物质对添加剂的添加顺序也有不同的反应。与 CPP 在组合系统中的保护作用相比，VC 在控制 ZnO NPs 诱导的协同毒性作用方面更强大。
京公网安备 11010802027423号