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Time-dependent and Pb-dependent antagonism and synergism towards Vibrio qinghaiensis sp.-Q67 within heavy metal mixtures†
RSC Advances ( IF 3.9 ) Pub Date : 2018-07-20 00:00:00 , DOI: 10.1039/c8ra04191a
Jin Zhang 1, 2 , Ting-Ting Ding 1 , Xin-Qin Dong 1 , Zhi-Qiang Bian 1
Affiliation  

Toxicity interaction has aroused many researchers' interest in the combined toxicity of pollutants. Recently, some published studies have shown that the toxicity of some mixture pollutants is time dependent and well correlated with certain components in the mixture. Therefore, to investigate whether toxicity interaction is affected by the exposure time or certain components, synergism and antagonism within typical environmental contaminants of heavy metal mixtures were analyzed in different exposure times. Herein, three binary and one ternary mixture systems were designed by using three heavy metals: cadmium chloride, lead chloride (Pb) and manganese(II) chloride tetrahydrate (Mn). For each mixture system, five mixture rays with different concentration ratios were arranged by direct equipartition ray design and uniform design ray methods. The toxicities of the three heavy metals and 20 mixture rays towards photobacteria Vibrio qinghaiensis sp.-Q67 (Q67) were determined by the established time-dependent microplate toxicity analysis (t-MTA) in different exposure durations of 0.25, 2, 4, 8 and 12 h. It was shown that the toxicities of three heavy metals (Cd, Pb and Mn) as well as their binary and ternary mixture rays to Q67 were also time dependent, but different metals or mixture rays showed different time characteristics. Surprisingly, some mixture rays exhibited antagonism or synergism with time dependency and the time characteristics varied in different mixture systems. Furthermore, the binary or ternary mixture systems with Pb displayed antagonism, while the Cd–Mn mixture system without Pb exhibited additive action or synergism, which indicated that Pb was probably the causative agent of antagonism produced by mixtures.

中文翻译:

重金属混合物中对青海弧菌-Q67的时间依赖性和铅依赖性拮抗和协同作用†

毒性相互作用引起了许多研究人员对污染物综合毒性的兴趣。最近,一些已发表的研究表明,某些混合物污染物的毒性具有时间依赖性,并且与混合物中的某些成分密切相关。因此,为了研究毒性相互作用是否受暴露时间或某些组分的影响,分析了重金属混合物在不同暴露时间下典型环境污染物的协同作用和拮抗作用。在此,使用三种重金属:氯化镉、氯化铅(Pb)和锰(II) 氯化物四水合物 (Mn)。对于每个混合系统,通过直接均分射线设计和均匀设计射线方法排列了五种不同浓度比的混合射线。三种重金属及20种混合射线对青海弧菌的毒性研究sp.-Q67 (Q67) 是通过已建立的时间依赖性微孔板毒性分析 (t-MTA) 在 0.25、2、4、8 和 12 小时的不同暴露时间下确定的。结果表明,三种重金属(Cd、Pb和Mn)及其二元和三元混合射线对Q67的毒性也呈时间依赖性,但不同的金属或混合射线表现出不同的时间特征。令人惊讶的是,一些混合射线表现出与时间相关的拮抗或协同作用,并且时间特性在不同的混合系统中有所不同。此外,含Pb的二元或三元混合物体系表现出拮抗作用,而不含Pb的Cd-Mn混合物体系表现出相加作用或协同作用,这表明Pb可能是混合物产生拮抗作用的原因。
更新日期:2018-07-20
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