Cobalt(III)‐Catalyzed C−H Activation: Counter Anion Triggered Desilylative Direct ortho‐Vinylation of Secondary Benzamides,Advanced Synthesis & Catalysis

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Cobalt(III)‐Catalyzed C−H Activation: Counter Anion Triggered Desilylative Direct ortho‐Vinylation of Secondary Benzamides
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-08-03 , DOI: 10.1002/adsc.201800649
Nachimuthu Muniraj ₁ , Kandikere Ramaiah Prabhu ₁

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A Co(III)‐catalyzed counter anion triggered desilylative direct ortho‐vinylation of secondary benzamides is reported. The reaction furnishes the alkenylated product, exclusively, and no formation of the possible cyclic products was observed. Mechanistic studies suggest that the counter anion, [SbF₆]⁻, plays a crucial role in the desilylation. The utility of alkynylsilanes instead of terminal alkynes turned out to be a potential and practical approach to obtain the corresponding vinylated products. The developed methodology is compatible with a variety of functional groups.

中文翻译：

钴（III）催化的CH活化：抗衡阴离子引发仲苄酰胺的脱甲硅烷基化的直接邻苯二甲酰化

据报道，Co（III）催化的抗衡阴离子引发了仲苯甲酰胺的脱甲硅烷基化的直接邻位乙烯基化。该反应仅提供烯基化产物，并且未观察到可能的环状产物的形成。机理研究表明，抗衡阴离子[SbF ₆ ] ^-在去甲硅烷基化中起关键作用。事实证明，使用炔基硅烷代替末端炔烃是获得相应的乙烯基化产物的潜在且实用的方法。所开发的方法与各种功能组兼容。

更新日期：2018-08-03

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