Nanotopography‐Promoted Formation of Axon Collateral Branches of Hippocampal Neurons,Small

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Nanotopography‐Promoted Formation of Axon Collateral Branches of Hippocampal Neurons
Small ( IF 13.0 ) Pub Date : 2018-07-20 , DOI: 10.1002/smll.201801763
Jeongyeon Seo ₁ , Juan Kim ₁ , Sunghoon Joo ₁ , Ji Yu Choi ₁ , Kyungtae Kang ₂ , Woo Kyung Cho ₃ , Insung S Choi ₁

Affiliation

Axon collateral branches, as a key structural motif of neurons, allow neurons to integrate information from highly interconnected, divergent networks by establishing terminal boutons. Although physical cues are generally known to have a comprehensive range of effects on neuronal development, their involvement in axonal branching remains elusive. Herein, it is demonstrated that the nanopillar arrays significantly increase the number of axon collateral branches and also promote their growth. Immunostaining and biochemical analyses indicate that the physical interactions between the nanopillars and the neurons give rise to lateral filopodia at the axon shaft via cytoskeletal changes, leading to the formation of axonal branches. This report, demonstrates that nanotopography regulates axonal branching, and provides a guideline for the design of sophisticated neuron‐based devices and scaffolds for neuro‐engineering.

中文翻译：

纳米形貌促进海马神经元轴突侧支的形成

轴突侧支作为神经元的关键结构基序，允许神经元通过建立终端纽扣来整合来自高度互连、发散网络的信息。尽管众所周知物理信号对神经元发育具有广泛的影响，但它们对轴突分支的参与仍然难以捉摸。在此，证明纳米柱阵列显着增加了轴突侧支分支的数量并促进其生长。免疫染色和生化分析表明，纳米柱和神经元之间的物理相互作用通过细胞骨架变化在轴突轴上产生侧丝状伪足，从而导致轴突分支的形成。该报告证明了纳米形貌调节轴突分支，并为神经工程的复杂的基于神经元的设备和支架的设计提供了指导。

更新日期：2018-07-20

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