Insights into 2D MXenes for Versatile Biomedical Applications: Current Advances and Challenges Ahead,Advanced Science

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Insights into 2D MXenes for Versatile Biomedical Applications: Current Advances and Challenges Ahead
Advanced Science ( IF 14.3 ) Pub Date : 2018-07-19 , DOI: 10.1002/advs.201800518
Han Lin _{1,

2} , Yu Chen ₁ , Jianlin Shi ₁

Affiliation

Great and interdisciplinary research efforts have been devoted to the biomedical applications of 2D materials because of their unique planar structure and prominent physiochemical properties. Generally, ceramic‐based biomaterials, fabricated by high‐temperature solid‐phase reactions, are preferred as bone scaffolds in hard tissue engineering because of their controllable biocompatibility and satisfactory mechanical property, but their potential biomedical applications in disease theranostics are paid much less attention, mainly due to their lack of related material functionalities for possibly entering and circulating within the vascular system. The emerging 2D MXenes, a family of ultrathin atomic nanosheet materials derived from MAX phase ceramics, are currently booming as novel inorganic nanosystems for biologic and biomedical applications. The metallic conductivity, hydrophilic nature, and other unique physiochemical performances make it possible for the 2D MXenes to meet the strict requirements of biomedicine. This work introduces the very recent progress and novel paradigms of 2D MXenes for state‐of‐the‐art biomedical applications, focusing on the design/synthesis strategies, therapeutic modalities, diagnostic imaging, biosensing, antimicrobial, and biosafety issues. It is highly expected that the elaborately engineered ultrathin MXenes nanosheets will become one of the most attractive biocompatible inorganic nanoplatforms for multiple and extensive biomedical applications to profit the clinical translation of nanomedicine.

中文翻译：

深入了解 2D MXene 的多功能生物医学应用：当前进展和未来挑战

由于二维材料独特的平面结构和突出的理化性质，大量的跨学科研究工作致力于二维材料的生物医学应用。一般来说，通过高温固相反应制备的陶瓷基生物材料因其可控的生物相容性和令人满意的机械性能而优选作为硬组织工程中的骨支架，但其在疾病治疗诊断学中潜在的生物医学应用却很少受到关注。主要是由于它们缺乏可能进入血管系统并在血管系统内循环的相关材料功能。新兴的 2D MXenes 是一系列源自 MAX 相陶瓷的超薄原子纳米片材料，目前作为生物和生物医学应用的新型无机纳米系统正在蓬勃发展。金属导电性、亲水性和其他独特的理化性能使2D MXenes能够满足生物医学的严格要求。这项工作介绍了 2D MXene 在最先进的生物医学应用中的最新进展和新颖范例，重点关注设计/合成策略、治疗方式、诊断成像、生物传感、抗菌和生物安全问题。人们高度期望精心设计的超薄 MXenes 纳米片将成为最具吸引力的生物相容性无机纳米平台之一，用于多种和广泛的生物医学应用，以促进纳米医学的临床转化。

更新日期：2018-07-19

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