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Renewable Time‐Responsive DNA Circuits
Small ( IF 13.0 ) Pub Date : 2018-07-18 , DOI: 10.1002/smll.201801470
Sudhanshu Garg 1 , Shalin Shah 2 , Hieu Bui 3, 4 , Tianqi Song 5 , Reem Mokhtar 5 , John Reif 2, 5
Affiliation  

DNA devices have been shown to be capable of evaluating Boolean logic. Several robust designs for DNA circuits have been demonstrated. Some prior DNA‐based circuits are use‐once circuits since the gate motifs of the DNA circuits get permanently destroyed as a side effect of the computation, and hence cannot respond correctly to subsequent changes in inputs. Other DNA‐based circuits use a large reservoir of buffered gates to replace the working gates of the circuit and can be used to drive a finite number of computation cycles. In many applications of DNA circuits, the inputs are inherently asynchronous, and this necessitates that the DNA circuits be asynchronous: the output must always be correct regardless of differences in the arrival time of inputs. This paper demonstrates: 1) renewable DNA circuits, which can be manually reverted to their original state by addition of DNA strands, and 2) time‐responsive DNA circuits, where if the inputs change over time, the DNA circuit can recompute the output correctly based on the new inputs, that are manually added after the system has been reset. The properties of renewable, asynchronous, and time‐responsiveness appear to be central to molecular‐scale systems; for example, self‐regulation in cellular organisms.

中文翻译:


可再生时间响应 DNA 电路



DNA 设备已被证明能够评估布尔逻辑。几种稳健的 DNA 电路设计已经得到证实。一些先前的基于 DNA 的电路是一次性电路,因为 DNA 电路的门基序由于计算的副作用而被永久破坏,因此无法正确响应输入的后续变化。其他基于 DNA 的电路使用大量缓冲门来代替电路的工作门,并可用于驱动有限数量的计算周期。在 DNA 电路的许多应用中,输入本质上是异步的,这使得 DNA 电路必须是异步的:无论输入的到达时间如何差异,输出都必须始终正确。本文演示了:1) 可再生 DNA 电路,可以通过添加 DNA 链手动恢复到原始状态;2) 时间响应 DNA 电路,如果输入随时间变化,DNA 电路可以正确重新计算输出基于系统重置后手动添加的新输入。可再生、异步和时间响应的特性似乎是分子尺度系统的核心。例如,细胞有机体的自我调节。
更新日期:2018-07-18
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