Clinical Question In adults and children prescribed antibiotics, is co-administration of a probiotic associated with a lower risk of symptomatic Clostridium difficile infection without an increase in adverse events? Bottom Line Moderate-quality evidence suggests that probiotics are associated with a lower risk of C difficile infection and very low-quality evidence suggests that probiotics are associated with fewer adverse events vs placebo or no treatment.

中文翻译：

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益生菌预防接受抗生素患者的艰难梭菌感染

临床问题 在使用抗生素的成人和儿童中，联合使用益生菌是否会降低有症状的艰难梭菌感染的风险，而不会增加不良事件？底线 中等质量的证据表明益生菌与较低的艰难梭菌感染风险相关，而极低质量的证据表明益生菌与安慰剂或不治疗相比不良事件更少。