Crystalline Curcumin bioMOF Obtained by Precipitation in Supercritical CO2 and Structural Determination by Electron Diffraction Tomography,ACS Sustainable Chemistry & Engineering

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Crystalline Curcumin bioMOF Obtained by Precipitation in Supercritical CO2 and Structural Determination by Electron Diffraction Tomography
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2018-07-19 00:00:00 , DOI: 10.1021/acssuschemeng.8b02738
Nuria Portolés-Gil ₁ , Arianna Lanza ₂ , Núria Aliaga-Alcalde _{1,

3} , José A. Ayllón ₄ , Mauro Gemmi ₂ , Enrico Mugnaioli ₂ , Ana M. López-Periago ₁ , Concepción Domingo ₁

Affiliation

This article analyzes the use of supercritical CO₂ green technology in the reactive crystallization processes involved in the formation of a bioMOF that contains curcumin and Zn^II metal centers. A new phase with a [Zn(curcumin)]_n composition, termed sc-CCMOF-1, is presented. The developed scCO₂ protocol allows high yields of the small-sized crystalline material, which was characterized by the use of the recently developed electron diffraction tomography method applied to the resolution of submicrometric crystals. A remarkable 3D macrostructure with a complex morphology was obtained. To analyze the crystallization mechanism, multiple identical runs were performed under similar experimental conditions to study in each time period the crystal growth progress ex situ by X-ray diffraction and scanning electron microscopy. These experiments indicated that the process to achieve the sc-CCMOF-1 in a crystalline form involves the formation of amorphous or semicrystalline metastable phases that derived into hierarchical stable and crystalline nanoflower aggregates. In addition, a potential therapeutic application of the bioMOF has been tested by studying the released of the curcumin molecule at neutral pH.

中文翻译：

在超临界CO _2中沉淀获得的姜黄素结晶bioMOF和电子衍射层析成像确定结构。

本文分析了超临界CO ₂ green技术在反应生物结晶过程中的使用，该反应过程涉及包含姜黄素和Zn ^II金属中心的bioMOF的形成。提出了一种具有[Zn（姜黄素）] _n组成的新相，称为sc-CCMOF-1。研发的scCO ₂协议允许高收率的小尺寸晶体材料，其特征是使用最近开发的电子衍射层析成像方法，用于亚微米晶体的分辨率。获得了具有复杂形态的非凡的3D宏观结构。为了分析结晶机理，在相似的实验条件下进行了多次相同的运行，以在每个时间段内通过X射线衍射和扫描电子显微镜研究晶体生长的非原位生长。这些实验表明，以晶体形式获得sc-CCMOF-1的过程涉及非晶或半晶亚稳态相的形成，这些相衍生为层次稳定的晶体纳米花聚集体。此外，

更新日期：2018-07-19

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