Tip-Functionalized Au@Ag Nanorods as Ultrabright Surface-Enhanced Raman Scattering Probes for Bioimaging in Off-Resonance Mode,The Journal of Physical Chemistry C

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Tip-Functionalized Au@Ag Nanorods as Ultrabright Surface-Enhanced Raman Scattering Probes for Bioimaging in Off-Resonance Mode
The Journal of Physical Chemistry C ( IF 3.3 ) Pub Date : 2018-08-01 , DOI: 10.1021/acs.jpcc.8b04772
Boris N. Khlebtsov _{1,

2} , Daniil N. Bratashov ₂ , Nikolai G. Khlebtsov _{1,

2}

Affiliation

Surface-enhanced Raman scattering (SERS) performance of Au nanorods (AuNRs) can be enhanced by the tip adsorption of Raman molecules (RMs) through anisotropic polymer stabilization or through the embedding of RMs between AuNR cores and Ag shells of AuNR@RM@Ag composite particles. We propose a new strategy to design ultrabright SERS probes composed of high-aspect-ratio AuNRs with anisotropic Ag coatings, with preferred adsorption of RMs to open AuNR tips. Specifically, for 4-nitrobenzenethiol (NBT) concentrations above a threshold value c > c_tr, the fabricated Au@NBT@Ag particles had NBT-functionalized open Au tips, as well as anisotropic Ag shells grown on the AuNR sides. The SERS response of these probes with an optimal Ag shell was highest in the off-resonance mode, when the excitation wavelength was far from the plasmon resonance of the Au@NBT@Ag composites. Growing the Ag shell further to completely cover the AuNRs decreased the SERS enhancement. For biocompatibility and stability, the probes were additionally covered with a thin silica layer. Under optimal conditions, the probes demonstrated superstrong and superstable SERS spectra, as compared to those from common SERS tags (AuNRs, nanostars, and Au@Ag NRs) with surface-adsorbed NBT. The excellent SERS performance of the developed ultrabright probes is illustrated by single-particle detection of SERS spectra, Raman imaging of living cells, and deep tissue imaging.

中文翻译：

尖端功能化的Au @ Ag纳米棒作为超亮表面增强拉曼散射探针，用于非共振模式下的生物成像。

金纳米棒（AuNRs）的表面增强拉曼散射（SERS）性能可通过各向异性聚合物稳定化或通过将RMs嵌入AuNR @ RM @ Ag的AuNR核和Ag壳之间来实现，以提高Raman分子（RM）的尖端吸附能力。复合颗粒。我们提出了一种新的策略来设计超高亮SERS探针，该探针由具有高纵横比的AuNRs和各向异性的Ag涂层组成，并具有对RMs的优选吸附作用，以打开AuNR尖端。具体来说，对于4-硝基苯硫醇（NBT）浓度高于阈值c > c _tr，制成的Au @ NBT @ Ag颗粒具有NBT功能化的开放Au尖端，以及在AuNR侧面生长的各向异性Ag壳。当激发波长远离Au @ NBT @ Ag复合材料的等离子体激元共振时，具有最佳Ag壳的这些探针的SERS响应在非共振模式下最高。进一步生长Ag壳以完全覆盖AuNRs降低了SERS增强。为了生物相容性和稳定性，探针还另外覆盖有一层薄二氧化硅层。在最佳条件下，与具有表面吸附NBT的普通SERS标签（AuNR，纳米星和Au @ Ag NR）相比，这些探针显示出超强和超稳定的SERS光谱。通过对SERS光谱进行单粒子检测，可以证明已开发的超亮探针具有出色的SERS性能，

更新日期：2018-08-01

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