Persistence of antibacterial drugs for prolonged period in milk increases the probability of antimicrobial resistance progress. Ceftizoxime was found to be excreted in milk for a prolonged period in goats, cows and buffaloes following intravenous injection of ceftriaxone and ceftizoxime. A single dose of ceftriaxone was administered intravenously in healthy control goats (group I) and a single oral dose of the commercial mammary protective polyherbal drug (1.9 gm) was given one hour prior to intravenous ceftriaxone injection in healthy (group II) and induced mastitic (group III) goats to evaluate milk disposition of ceftizoxime following single intravenous dosing of ceftriaxone at 42.25 mg kg^-1.Ceftriaxone/ceftizoxime was analyzed by HPLC. The t_1/2α and t_1/2β values were 14.755 ± 2.733 and 149.079 ± 18.565 hour, respectively indicating prolonged persistence of ceftizoxime in milk. The polyherbal drug increased the milk concentration at later hours and hastened the excretion of ceftizoxime from milk compared to control group. Ceftriaxone could not be detected in milk. The study suggested that adjunct single or repeated therapy of the polyherbal drug may cause non persistence of ceftriaxone and shorter persistence of ceftizoxime in milk.

中文翻译：

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多草药药物的潜力，可防止细菌对抗生素产生抗药性。

牛奶中长时间存在抗菌药物会增加抗菌素耐药性进展的可能性。头孢曲松和头孢唑肟静脉注射后，发现头孢唑肟在山羊，牛和水牛中长时间排泄在牛奶中。在健康对照山羊（II组）中静脉注射头孢曲松前一小时，在健康对照山羊（I组）中静脉注射单剂量的头孢曲松钠，在口服头孢曲松酮前一小时给予单次口服剂量的商业性乳腺保护性多草药药物（1.9 gm）。 （第三组）山羊以42.25mg / kg ^-1静脉注射头孢曲松后评价头孢唑肟的乳汁处置。通过HPLC分析头孢曲松/头孢唑肟。t _1/ 2α和t _1/2β值分别为14.755±2.733和149.079±18.565小时，表明头孢唑肟在牛奶中的持续存在时间较长。与对照组相比，多草药药物在以后的几个小时中增加了牛奶的浓度，并加快了头孢唑肟从牛奶中的排泄。牛奶中未检出头孢曲松。该研究表明，多草药药物的辅助单次或重复治疗可能会导致牛奶中头孢曲松的非持久性和头孢唑肟的持久性缩短。