Sharp-featured Au@Ag core/shell nanocuboid synthesis and the label-free ultrasensitive SERS detection of protein single-point mutations†,Materials Chemistry Frontiers

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Sharp-featured Au@Ag core/shell nanocuboid synthesis and the label-free ultrasensitive SERS detection of protein single-point mutations†
Materials Chemistry Frontiers ( IF 7 ) Pub Date : 2018-07-18 00:00:00 , DOI: 10.1039/c8qm00185e
Guopeng Tu _{1,

2,

3,

4,

5} , Ntirikwendera Deogratias _{1,

2,

3,

4,

5} , Meng Xu _{1,

2,

3,

4,

5} , Xiaowei Li _{3,

4,

5,

6} , Jiajia Liu _{1,

2,

3,

4,

5} , Lan Jiang _{3,

4,

5,

6} , Yanlian Yang _{4,

5,

7,

8} , Jiatao Zhang _{1,

2,

3,

4,

5}

Affiliation

Sharp-featured Au@Ag core/shell nanocuboids were synthesized. Simulation and experimental results demonstrated that the sharp features and in-cuboid, out-of-cuboid LSPR coupling of the nanocuboids enabled high SERS activities. The ultrasensitive detection of single-point mutations of TDP-43 proteins was demonstrated at 10 pM for the first time. This could be a general strategy for single-point mutation detection in proteins.

中文翻译：

特色鲜明的Au @ Ag核/壳纳米立方合成和蛋白质单点突变的无标记超灵敏SERS检测†

合成了特征鲜明的Au @ Ag核/壳纳米立方。仿真和实验结果表明，纳米立方的鲜明特征和立方内，立方外LSPR耦合使SERS活性高。TDP-43蛋白单点突变的超灵敏检测首次显示为10 pM。这可能是蛋白质中单点突变检测的一般策略。

更新日期：2018-07-18

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