Polyetheretherketone (PEEK) has the potential to replace traditional metallic materials as an orthopedic and dental implant because its elastic modulus is similar to natural bone, although its intrinsic bioinertness hampers its clinical application. In this study, sulfonate groups were introduced onto the PEEK surface through a single-step ultraviolet-initiated graft polymerization of vinylsulfonic acid sodium. Diffuse reflectance Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy analyses confirmed the successful attachment of sulfonate groups to the PEEK surfaces. A decreased angle of contact suggested there was an increase in hydrophilicity as a result of endowing the PEEK surface with sulfonate groups. Atomic force microscopy revealed there to be no significant changes in surface topology and roughness as a result of the surface modification. In vitro cell adhesion, viability assay, alkaline phosphatase activity and extracellular matrix mineralization analyses, and real-time polymerase chain reaction analyses showed increased adhesion, spreading, and proliferation, and osteogenic differentiation capacity on the surface-sulfonated PEEK substrate compared to those on the unmodified PEEK. Thus, the results indicated that the surface-sulfonated PEEK has a great potential for use in orthopedic and dental implants.

中文翻译：

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通过一步一步紫外引发的接枝聚合反应，增强的成骨细胞对表面磺化的聚醚醚酮的响应

聚醚醚酮（PEEK）的弹性模量与天然骨相似，尽管其固有的生物惰性会妨碍其临床应用，但它有可能替代传统的金属材料作为骨科和牙科植入物。在这项研究中，通过单步紫外线引发的乙烯基磺酸钠的接枝聚合，将磺酸酯基团引入到PEEK表面。漫反射傅里叶变换红外光谱和X射线光电子能谱分析证实了磺酸盐基团成功地附着在PEEK表面上。减小的接触角表明，由于用磺酸盐基团赋予PEEK表面，亲水性增加。原子力显微镜显示，由于表面改性，表面拓扑和粗糙度没有显着变化。体外细胞粘附，活力测定，碱性磷酸酶活性和细胞外基质矿化分析以及实时聚合酶链反应分析显示，与表面磺化的PEEK底物相比，表面磺化PEEK底物的粘附，扩散和增殖以及成骨分化能力增强。未经修改的PEEK。因此，结果表明表面磺化的PEEK具有用于骨科和牙科植入物的巨大潜力。与未改性的PEEK相比，表面磺化PEEK底物的表面活性，增殖和成骨分化能力。因此，结果表明表面磺化的PEEK具有用于整形外科和牙科植入物中的巨大潜力。与未改性的PEEK相比，表面磺化PEEK底物的表面活性，增殖和成骨分化能力。因此，结果表明表面磺化的PEEK具有用于整形外科和牙科植入物中的巨大潜力。