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Pharmacology and Therapeutic Potential of the 5-HT7 Receptor.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-09-04 , DOI: 10.1021/acschemneuro.8b00283 Kevin M Blattner 1 , Daniel J Canney 1 , Douglas A Pippin 2 , Benjamin E Blass 1
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2018-09-04 , DOI: 10.1021/acschemneuro.8b00283 Kevin M Blattner 1 , Daniel J Canney 1 , Douglas A Pippin 2 , Benjamin E Blass 1
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It is well-documented that serotonin (5-HT) exerts its pharmacological effects through a series of 5-HT receptors. The most recently identified member of this family, 5-HT7, was first identified in 1993. Over the course of the last 25 years, this receptor has been the subject of intense investigation, and it has been demonstrated that 5-HT7 plays an important role in a wide range of pharmacological processes. As a result of these findings, modulation of 5-HT7 activity has been the focus of numerous drug discovery and development programs. This review provides an overview of the roles of 5-HT7 in normal physiology and the therapeutic potential of this interesting drug target.
中文翻译：
5-HT7受体的药理学和治疗潜能。
众所周知，5-羟色胺（5-HT）通过一系列5-HT受体发挥其药理作用。该家族中最近鉴定出的成员5-HT7于1993年被首次鉴定。在过去的25年中，该受体一直受到广泛研究，并且已证明5-HT7发挥了重要作用。在广泛的药理过程中的作用。这些发现的结果是，调节5-HT 7活性一直是许多药物发现和开发计划的重点。这篇综述概述了5-HT7在正常生理中的作用以及这种有趣的药物靶标的治疗潜力。
更新日期：2018-07-18
中文翻译：
5-HT7受体的药理学和治疗潜能。
众所周知，5-羟色胺（5-HT）通过一系列5-HT受体发挥其药理作用。该家族中最近鉴定出的成员5-HT7于1993年被首次鉴定。在过去的25年中，该受体一直受到广泛研究，并且已证明5-HT7发挥了重要作用。在广泛的药理过程中的作用。这些发现的结果是，调节5-HT 7活性一直是许多药物发现和开发计划的重点。这篇综述概述了5-HT7在正常生理中的作用以及这种有趣的药物靶标的治疗潜力。
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