Hydrothermal reactions of (benzylazanediyl)bis(methylene)-diphosphonic acid (H₄L¹) or (benzene-1,3,5-triyltris(methylene))triphosphonic acid (H₆L²) with Fe(III)/Cu(II) nitrate and 4, 4′-bipy or 2, 2′-bipy result in five new phosphonates, namely, [FeHL¹(H₂O)]_n (1), {[Cu₂L¹(4, 4′-bipy)_0.5(H₂O)]·0.25H₂O}_n (2), [Cu₂H₂L²(4, 4′-bipy)(H₂O)₂]_n (3), [CuH₄L²(2, 2′-bipy)]_n (4) and [Cu₂(H₄L²)₂(2, 2′-bipy)₂(H₂O)₄] (5), respectively. X-ray structural analysis indicates that 2 and 3 feature 3D framework structures with 3, 3, 3, 4-connected and 4, 5-connected topology; 1 and 4 display 1D chain structures, while 5 has a dimer structure. The di- or trisphosphonate ligands (H₄L¹ and H₆L²) in the five complexes adopt different coordination modes and auxiliary ligands (4, 4′-bipy and 2, 2′-bipy) control the dimensionality of the final complexes. The superoxide dismutase (SOD) activities of 2–5 were assessed by modified nitrobluetetrazolium (NBT) assay. The IC₅₀ values required to yield 50% inhibition of the reduction of NBT are 1.84, 2.02, 6.95 and 1.70 μM for 2–5, respectively, demonstrating better SOD-like activity than most of the Cu-SOD mimic enzymes reported in literatures. Among them, 2 and 3 have good stability and reusability under the simulative physiological conditions. The dismutation of 4 and 5 toward superoxide anion radicals can be attributed to the synergistic effect of the decomposition products of 4 and 5 containing Cu(II) and [H₄L²]^2- with or without 2, 2′-bipy or Cu(II) and 2, 2′-bipy, which were identified by liquid mass spectrometry (LC/MS). The magnetic properties of complexes 1–4 were also investigated, indicating the presence of magnetic exchange between metal ions. The results show that 1 and 3 exhibit antiferromagnetic interactions, while 2 and 4 show ferromagnetic interactions between metal centres.

（苄基氮杂二基）双（亚甲基）-二膦酸（H ₄ L ¹）或（苯-1,3,5-三基三（亚甲基））三膦酸（H ₆ L ² ）与Fe（III）/ Cu（ II）硝酸盐和4，4'-联吡啶或2，2，'-联吡啶产生五个新的膦酸酯，即[FeHL ¹（H ₂ O）] _n（1），{[Cu ₂ L ¹（4，4' -bipy）_0.5（H ₂ O）]·0.25H ₂ O} _n（2），[Cu ₂ H ₂ L ²（4，4'-bipy）（H ₂ O）₂ ] _n（3），[CuH ₄ L ²（2，2' -bipy）] _n（4）和[Cu ₂（H ₄ L ²）₂（2，2'-bipy）₂（H ₂ O）₄ ]（5）。X射线结构分析表明2和3具有3、3、3、4连接和4、5连接拓扑的3D框架结构。图1和4显示1D链结构，而5显示二聚体结构。二膦酸酯或三膦酸酯配体（H五个配合物中的₄ L ¹和H ₆ L ² ）采用不同的配位方式，辅助配体（4、4'-bipy和2，2'-bipy）控制最终配合物的尺寸。通过改良的硝基蓝四唑（NBT）分析评估了2 – 5的超氧化物歧化酶（SOD）活性。抑制50％的NBT还原所需的IC ₅₀值为2 – 5分别为1.84、2.02、6.95和1.70μM ，证明其比类文献中报道的大多数Cu-SOD模拟酶具有更好的SOD样活性。其中2和3在模拟生理条件下具有良好的稳定性和可重用性。的歧化4和5朝向超氧化物阴离子自由基可以归因于的分解产物的协同效应4和5含有Cu（II）和[H ₄大号² ] ^2-有或没有2，2'-联吡啶或Cu （II）和2，2'-联吡啶，通过液相质谱（LC / MS）鉴定。复合物的磁特性1 - 4也进行了研究，表明金属离子之间的磁交换的存在。结果显示1和3表现出反铁磁相互作用，而2和4表现出金属中心之间的铁磁相互作用。