MIL-88A (Fe) MOF crystals were nucleated and grown around a polymer core containing superparamagnetic nanoparticles to assemble a new class of biocompatible particles for magnetophoretic drug delivery of dopamine. The carrier enabled efficient targeted release, dopamine protection from oxidative damage, long-term delivery and improved drug delivery cost-efficiency. After loading, dopamine was stable within the carrier and did not undergo oxidation. Drug release monitoring via spectrofluorimetry revealed a shorter burst effect and higher release efficiency than silica based carriers. The in vitro cytotoxicity at different MOF concentrations and sizes was assessed using PC12 cells as the neuronal cell model. The drug was directly uptaken into the PC12 cells avoiding possible side effects due to oxidation occurring in the extracellular environment.

中文翻译：

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用于原位多巴胺递送的基于 MOF 的载体†

MIL-88A (Fe) MOF 晶体在含有超顺磁性纳米颗粒的聚合物核心周围成核并生长，以组装一类新的生物相容性颗粒，用于多巴胺的磁泳药物输送。该载体实现了高效的靶向释放、多巴胺保护免受氧化损伤、长期给药并提高了给药成本效益。加载后，多巴胺在载体内是稳定的，不会发生氧化。通过荧光分光光度法监测药物释放显示比基于二氧化硅的载体更短的爆发效应和更高的释放效率。体外的使用 PC12 细胞作为神经元细胞模型评估不同 MOF 浓度和大小的细胞毒性。该药物被直接吸收到 PC12 细胞中，避免了由于细胞外环境中发生的氧化而可能产生的副作用。