The high reactivity of alkyl halides towards nucleophiles renders them as acutely toxic and mutagenic agents. Therefore, it is urgent to develop simple, sensitive, and selective methods for the detection of alkylating agents in a wide range of scenarios. Herein, we have designed and synthesized a novel cyclometalated iridium(III) complex Ir_1 as a rapid and effective chemosensor for a range of alkyl halides based on cycloaddition reaction. Ir_1 displayed an enhanced luminescence with the increase of BnBr-thiourea concentration, within a linear range of 0.8–8 μM BnBr-thiourea, and the detection limit at a signal-to-noise ratio of 3 was as low as 0.39 μM.

卤代烷对亲核试剂的高反应活性使其成为急性毒性和诱变剂。因此，迫切需要开发一种简单，灵敏和选择性的方法来在多种情况下检测烷基化剂。在这里，我们已经设计并合成了一种新型的环金属化铱（III）络合物Ir_1，作为基于环加成反应的一系列烷基卤的快速有效的化学传感器。Ir_1在0.8–8μMBnBr-硫脲的线性范围内随BnBr-硫脲浓度的增加而显示出增强的发光，并且在3的信噪比下的检测极限低至0.39μM。