Copper‐Catalyzed Synthesis of 3‐NO2 Quinolines from o‐Azidobenzaldehyde and Nitro‐olefins and its Application in the Concise Synthesis of Quindolines,Advanced Synthesis & Catalysis

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Copper‐Catalyzed Synthesis of 3‐NO2 Quinolines from o‐Azidobenzaldehyde and Nitro‐olefins and its Application in the Concise Synthesis of Quindolines
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-08-09 , DOI: 10.1002/adsc.201800773
Lei Zheng ₁ , Zhigang Zeng ₂ , Qiong Yan ₁ , Fengcheng Jia ₁ , Lihui Jia ₁ , Yunfeng Chen ₁

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An efficient copper‐catalyzed cyclization of o‐azidobenzaldehyde and nitro‐olefins was developed. This reaction proceeds under solvent‐free conditions and displays broad functional group compatibility and affords 3‐nitroquinolines in good to excellent yields. The synthetic utility of this strategy is illustrated by the concise construction of quindolines in only three steps, which renders the reaction more practical.

中文翻译：

铜催化邻叠氮基苯甲醛和硝基烯烃合成3-NO2喹啉及其在喹啉的简捷合成中的应用

开发了一种高效的铜催化邻位叠氮基甲醛和硝基烯烃的环化反应。该反应在无溶剂条件下进行，并显示出广泛的官能团相容性，并能以优异的产率获得3-硝基喹啉。该策略的合成效用通过仅三个步骤的喹啉的简明结构来说明，这使反应更加实用。

更新日期：2018-08-09

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