Organocatalytic Enantioselective Strecker Reaction with Seven‐Membered Cyclic Imines,Advanced Synthesis & Catalysis

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Organocatalytic Enantioselective Strecker Reaction with Seven‐Membered Cyclic Imines
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-08-09 , DOI: 10.1002/adsc.201800754
Carles Lluna-Galán ₁ , Gonzalo Blay ₁ , Isabel Fernández ₁ , M. Carmen Muñoz ₂ , José R. Pedro ₁ , Carlos Vila ₁

Affiliation

A highly enantioselective Strecker reaction with dibenzo[b,f][1,4]oxazepines has been described using a dihydroquinine‐derived thiourea as organocatalyst. The reaction affords chiral 10,11‐dihydrodibenzo[b,f][1,4]oxazepine 11‐carbonitrile derivatives in excellent yields (up to 99%) and excellent enantioselectivities (up to 98%) under mild reaction conditions.

中文翻译：

七元环亚胺的有机催化对映选择性Strecker反应

已经描述了使用二氢奎宁衍生的硫脲作为有机催化剂与二苯并[ b，f ] [1,4]氧杂氮杂卓的高度对映选择性斯特雷克反应。在温和的反应条件下，该反应可制得手性10,11-二氢二苯并[ b，f ] [1,4]氮杂氮杂11-腈衍生物，且收率极高（高达99％）和对映选择性（最高达98％）。

更新日期：2018-08-09

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