Desymmetrization of Achiral Heterobicyclic Alkenes through Catalytic Asymmetric Hydrophosphination,Chemistry - An Asian Journal

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Desymmetrization of Achiral Heterobicyclic Alkenes through Catalytic Asymmetric Hydrophosphination
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2018-09-05 , DOI: 10.1002/asia.201801061
Abdul Sadeer ₁ , Yew Jin Ong ₁ , Tadayuki Kojima ₁ , Ce Qing Foo ₁ , Yongxin Li ₁ , Sumod A. Pullarkat ₁ , Pak-Hing Leung ₁

Affiliation

Asymmetric addition of diarylphosphines to oxa‐ and azabicyclic alkenes proceeded in the presence of a chiral phosphapalladacycle catalyst and a mild acid at room temperature to give exclusively the enantioenriched addition products in excellent yields and good selectivities. Three new chiral carbon centers were generated stereoselectively by the catalytic hydrophosphination reaction.

中文翻译：

通过催化不对称加氢磷酸化来实现非手性杂环双环烯烃的不对称化

在室温下，在手性磷apadaadacycle催化剂和温和酸的存在下，将二芳基膦不对称加成到氧杂和氮杂双环烯烃上，从而以优异的收率和良好的选择性仅得到对映体富集的加成产物。通过催化的加氢磷酸化反应立体选择性地生成了三个新的手性碳中心。

更新日期：2018-09-05

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