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5‐hydroxymethylfurfural‐ and fluorescein‐fused fluorescence probe of mast cells (RBL‐2H3): Synthesis, photophysical properties, and bioimaging
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2018-08-26 , DOI: 10.1111/cbdd.13367 Limin Huang 1 , Di Wei 1 , Zibo Wu 2 , Yajing Hou 1 , Yitong Xie 1 , Zhenru Liu 1 , Cheng Wang 1 , Delu Che 1 , Yibo Lei 2 , Huaizhen He 1
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2018-08-26 , DOI: 10.1111/cbdd.13367 Limin Huang 1 , Di Wei 1 , Zibo Wu 2 , Yajing Hou 1 , Yitong Xie 1 , Zhenru Liu 1 , Cheng Wang 1 , Delu Che 1 , Yibo Lei 2 , Huaizhen He 1
Affiliation
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A fluorescent probe (Fluo‐HMF) was developed via introduction of a furfural moiety into the fluorescein molecular skeleton, aiming at specially labeling cell membrane of mast cells. To illustrate its specificity, we designed and synthesized a series of fluorescent compounds based on fluorescein molecular skeleton. The fluorescent properties of Fluo‐HMF were investigated, which were in accordance with theoretical calculations. Compared with other fluorescein derivatives, Fluo‐HMF could specially label RBL‐2H3 cells. The results suggested that Fluo‐HMF could be used as a fluorescent probe for bioimaging on some related research of allergic mechanism.
中文翻译：
肥大细胞的5-羟甲基糠醛和荧光素融合荧光探针（RBL-2H3）：合成，光物理性质和生物成像
通过将糠醛部分引入荧光素分子骨架中，开发了一种荧光探针（Fluo- HMF），旨在专门标记肥大细胞的细胞膜。为了说明其特异性，我们设计并合成了一系列基于荧光素分子骨架的荧光化合物。根据理论计算，对Fluo- HMF的荧光性质进行了研究。与其他荧光素衍生物相比，Fluo- HMF可以专门标记RBL-2H3细胞。结果表明，Fluo- HMF可以作为生物成像的荧光探针，用于一些相关的过敏机理研究。
更新日期：2018-08-26
中文翻译：
肥大细胞的5-羟甲基糠醛和荧光素融合荧光探针（RBL-2H3）：合成，光物理性质和生物成像
通过将糠醛部分引入荧光素分子骨架中，开发了一种荧光探针（Fluo- HMF），旨在专门标记肥大细胞的细胞膜。为了说明其特异性，我们设计并合成了一系列基于荧光素分子骨架的荧光化合物。根据理论计算，对Fluo- HMF的荧光性质进行了研究。与其他荧光素衍生物相比，Fluo- HMF可以专门标记RBL-2H3细胞。结果表明，Fluo- HMF可以作为生物成像的荧光探针，用于一些相关的过敏机理研究。
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