DLLME is widely used as a sample preparation technique due to its unique advantages of fast extraction, low solvent consumption, high enrichment factors, and low cost. DLLME extracts are generally analyzed by gas or liquid chromatography coupled with different detection systems. However, GC or LC cannot analyze/separate many analytes due to their structural properties. Similarly, some of the analytes are not sensitive to commonly used detectors. In such cases, a derivatization process (chemical conversion) is often applied to improve the structural features of the analytes to make them compatible with separation and detection system. The coupling of derivatization with DLLME is a simple way to accomplish the job using minimum volumes of the derivatizing reagents and reducing their impact on workers and the environment. This review explains the different modes of DLLME coupled derivatizations, their applications, and green aspects in a systematic way.

DLLME具有快速提取，低溶剂消耗，高富集因子和低成本的独特优势，因此被广泛用作样品制备技术。DLLME提取物通常通过气相色谱法或液相色谱法以及不同的检测系统进行分析。但是，GC或LC由于其结构特性而无法分析/分离许多分析物。同样，某些分析物对常用的检测器不敏感。在这种情况下，通常采用衍生化过程（化学转化）来改善分析物的结构特征，以使其与分离和检测系统兼容。衍生化与DLLME的耦合是一种使用最少量的衍生化试剂并减少对工作人员和环境的影响来完成这项工作的简单方法。