An iridium complex-based probe for photoluminescence lifetime imaging of human carboxylesterase 2 in living cells†,Chemical Communications

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An iridium complex-based probe for photoluminescence lifetime imaging of human carboxylesterase 2 in living cells†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-07-18 00:00:00 , DOI: 10.1039/c8cc04481c
Zihe Yan _{1,

2,

3,

4} , Jinyu Wang _{1,

2,

3,

4} , Yanxin Zhang _{2,

3,

4,

5,

6} , Sichun Zhang _{1,

2,

3,

4} , Juan Qiao _{2,

3,

4,

5,

6} , Xinrong Zhang _{1,

2,

3,

4}

Affiliation

A novel photoluminescence lifetime probe (Ir-TB) has been developed for the detection and imaging of hCE2 in living cells. A large lifetime increase by around 300 ns after the enzymatic reaction makes it an ideal tool to distinguish hCE2-hydrolyzed probes from those non-hydrolyzed ones via PLIM for the first time.

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