Hospital wastewater contains high concentrations of pharmaceuticals, which pose risks to receiving waters. In this study, a pilot plant consisting of six moving bed biofilm reactors (MBBRs) in series (with the intention to integrate Biological Oxygen Demand (BOD) removal, nitrification and denitrification as well as prepolishing Chemical Oxygen Demand (COD) for ozonation) was built to integrate pharmaceutical removal and intermittent feeding of the latter reactors aimed for micropollutant removal. Based on the experimental resultss, nitrifying MBBRs achieved higher removal as compared to denitrifying MBBRs except for azithromycin, clarithromycin, diatrizoic acid, propranolol and trimethoprim. In the batch experiments, nitrifying MBBRs showed the ability to remove most of the analysed pharmaceuticals, with degradation rate constants ranging from 5.0 × 10⁻³ h⁻¹ to 2.6 h⁻¹. In general, the highest degradation rate constants were observed in the nitrifying MBBRs while the latter MBBRs showed lower degradation rate constant. However, when the degradation rate constants were normalised to the respective biomass, the intermittently fed reactors presented the highest specific activity. Out of the 22 compounds studied, 17 compounds were removed with more than 20%.

医院废水中含有高浓度的药品，这给接收水带来了风险。在这项研究中，一个由六个串联的移动床生物膜反应器（MBBR）组成的中试工厂（目的是整合生物需氧量（BOD）的去除，硝化和反硝化以及臭氧化的预抛光化学需氧量（COD））。旨在整合药物去除和间歇式进料的后继反应器，以去除微量污染物。根据实验结果，除阿奇霉素，克拉霉素，泛影酸，普萘洛尔和甲氧苄氨嘧啶外，硝化MBBR与反硝化MBBR相比去除率更高。在分批实验中，硝化的MBBR具有去除大多数分析药物的能力，降解速率常数范围为5。^-3  h ^-1至2.6 h ^-1。通常，在硝化的MBBR中观察到最高的降解速率常数，而后者的MBBR显示出较低的降解速率常数。然而，当将降解速率常数针对各个生物质标准化时，间歇进料的反应器呈现出最高的比活度。在研究的22种化合物中，有17种化合物的去除率超过20％。