Synthetic biology applies engineering concepts to build cells that perceive and process information. Examples include cells engineered to perform basic digital or analog computation. These circuits serve as basis for the construction of complex integrated cellular networks that offer manifold applications in fundamental and applied research. Here, we introduce the concept of using design approaches and molecular tools applied in synthetic biology for the construction of interconnected biohybrid materials systems with information processing functionality. We validate this concept by modularly assembling protein and polymer building blocks to generate stimulus-responsive materials. Guided by a quantitative mathematical model, we next interconnect these materials into a materials system that acts as both a signal detector and as an amplifier based on a built-in positive feedback loop. The functionality and versatility of this materials system is demonstrated by the detection of enzymatic activities and drugs. The modular design concept presented here thus represents a blueprint for integrating synthetic biology-inspired information-processing circuits into polymer materials. As integrated sensors and actuators, the resulting smart materials systems could provide novel solutions with broad perspectives in research and development.

中文翻译：

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合成生物学启发的信号放大材料系统设计

合成生物学应用工程概念来构建感知和处理信息的细胞。示例包括设计用于执行基本数字或模拟计算的单元。这些电路是构建复杂集成蜂窝网络的基础，在基础和应用研究中提供多种应用。在这里，我们介绍了使用合成生物学中应用的设计方法和分子工具来构建具有信息处理功能的互连生物混合材料系统的概念。我们通过模块化组装蛋白质和聚合物构建块来生成刺激响应材料来验证这一概念。在定量数学模型的指导下，接下来，我们将这些材料互连到一个材料系统中，该系统既充当信号检测器，又充当基于内置正反馈回路的放大器。该材料系统的功能性和多功能性通过检测酶活性和药物来证明。因此，这里提出的模块化设计概念代表了将受合成生物学启发的信息处理电路集成到聚合物材料中的蓝图。作为集成传感器和执行器，由此产生的智能材料系统可以提供具有广阔研究和开发前景的新颖解决方案。因此，这里提出的模块化设计概念代表了将受合成生物学启发的信息处理电路集成到聚合物材料中的蓝图。作为集成传感器和执行器，由此产生的智能材料系统可以提供具有广阔研究和开发前景的新颖解决方案。因此，这里提出的模块化设计概念代表了将受合成生物学启发的信息处理电路集成到聚合物材料中的蓝图。作为集成传感器和执行器，由此产生的智能材料系统可以提供具有广阔研究和开发前景的新颖解决方案。