The aim of this experiment is to obtain new antipyrine solubility data and the correlation equation parameters and thermodynamic parameters of the dissolution process. The solubility of antipyrine was experimentally measured in ten mono-solvents (methanol, ethanol, acetone, n-propanol, isopropanol, methyl acetate, n-butanol, isobutanol, ethyl acetate, water) and binary mixed solvents (ethanol–water) at 288.15 to 328.15 K using a gravimetric method under atmospheric pressure. In addition, the experimental solubility in the mono- and mixed solvents was correlated using the λh equation, modified Apelblat equation, nonrandom two-liquid equation, Wilson equation, and van't Hoff equation. Good agreement was found between the experimental values and correlation values calculated by all the selected equations. The thermodynamic parameters, Gibbs energy (∆G°_sol), molar enthalpy of dissolution (∆H°_sol), and molar entropy of dissolution (∆S°_sol) were also calculated. These experimental results are crucial for optimization of the antipyrine crystallization process.

该实验的目的是获得新的安替比林溶解度数据以及溶解过程的相关方程参数和热力学参数。安替比林的溶解度是在十种单溶剂（甲醇，乙醇，丙酮，正丙醇，异丙醇，乙酸甲酯，正丙醇，-丁醇，异丁醇，乙酸乙酯，水）和二元混合溶剂（乙醇-水），在大气压下使用重量法在288.15至328.15 K下进行。此外，使用λh方程，改良的Apelblat方程，非随机两液方程，Wilson方程和van't Hoff方程，可以将实验在单溶剂和混合溶剂中的溶解度进行关联。在所有选定方程式计算出的实验值和相关值之间找到了很好的一致性。还计算了热力学参数，吉布斯能量（G° _sol），溶解摩尔焓（ΔH° _sol）和溶解摩尔熵（ΔS° _sol）。这些实验结果对于优化安替比林结晶过程至关重要。