The potential application of some novel zwitterionic Natural Deep Eutectic Solvents, NADESs, based on betaine N,N,N-trimethylglycine and carboxylic acids (glycolic, phenylacetic and oxalic acid), has been evaluated in the synthesis of gold nanoparticles (AuNPs). AuNPs have been successfully obtained by reduction of gold(III) chloride trihydrate by ascorbic acid or sodium borohydride as reducing agents, without the use of any surfactant or capping agent. The effect of the different experimental conditions (nature of the reducing agent, temperature) has been discussed.

In the NADES composed of trimethylglycine and oxalic acid, no addition of a reductant was needed because AuNPs start to form immediately after the dissolution of the precursor salt. This result may open new perspectives in fine-tuning smart solvent characteristics and developing the most appropriate NADES for an environmentally friendly metal nanoparticle synthesis without using auxiliary chemicals.

已在金纳米颗粒（AuNPs）的合成中评估了一些基于甜菜碱N，N，N-三甲基甘氨酸和羧酸（乙醇酸，苯乙酸和草酸）的新型两性离子天然深共晶溶剂NADES的潜在应用。通过使用抗坏血酸或硼氢化钠作为还原剂还原三水合氯化金（III），而无需使用任何表面活性剂或封端剂，已成功获得了AuNPs。讨论了不同实验条件（还原剂的性质，温度）的影响。

在由三甲基甘氨酸和草酸组成的NADES中，不需要添加还原剂，因为AuNPs在前体盐溶解后立即开始形成。该结果可能会在微调智能溶剂特性和开发最合适的NADES而不使用辅助化学物质的环境友好的金属纳米粒子合成方面开辟新的视野。