Pyroelectric nanoplatform for NIR-II-triggered photothermal therapy with simultaneous pyroelectric dynamic therapy†,Materials Horizons

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Pyroelectric nanoplatform for NIR-II-triggered photothermal therapy with simultaneous pyroelectric dynamic therapy†
Materials Horizons ( IF 12.2 ) Pub Date : 2018-07-17 00:00:00 , DOI: 10.1039/c8mh00627j
Zhongmin Tang _{1,

2,

3,

4,

5} , Peiran Zhao _{5,

6,

7,

8,

9} , Dalong Ni _{1,

2,

3,

4,

5} , Yanyan Liu _{5,

6,

7,

8,

9} , Meng Zhang _{1,

2,

3,

4,

5} , Han Wang _{1,

2,

3,

4,

5} , Hua Zhang _{5,

10,

11,

12} , Hongbo Gao _{5,

10,

13,

14} , Zhenwei Yao _{5,

10,

11,

12} , Wenbo Bu _{1,

2,

3,

4,

5}

Affiliation

Photothermal therapy (PTT) has been attracting much attention because of its high efficiency and ease of use. Currently deployed PTT, however, shows two main deficiencies: limited penetration depth and interference from heat shock proteins (HSPs). Here we describe a specific application of a pyroelectric material, specifically SnSe-polyvinylpyrrolidone (SnSe-PVP) nanorods, for tumor photoacoustic imaging and PTT, accompanied by pyroelectric dynamic therapy (PEDT), utilizing near-infrared-II (NIR-II) light as the excitation trigger. Moreover, we used PEDT to generate reactive oxygen species (ROS) from SnSe-PVP nanorods and to have the ROS attack HSPs and cancer cells during heating and cooling. This work revealed a high potential for the application of pyroelectric materials in biomedicine, especially for PTT with PEDT via NIR-II light stimulation.

中文翻译：

热电纳米平台用于NIR-II触发的光热疗法并同时进行热电动力疗法†

光热疗法（PTT）由于其高效和易用性而备受关注。但是，当前部署的PTT表现出两个主要缺陷：有限的穿透深度和来自热激蛋白（HSP）的干扰。在这里，我们描述了热电材料（特别是SnSe-聚乙烯吡咯烷酮（SnSe-PVP）纳米棒）在肿瘤光声成像和PTT中的具体应用，以及热电动态疗法（PEDT），利用近红外II（NIR-II）光作为激励触发器。此外，我们使用PEDT从SnSe-PVP纳米棒中生成活性氧（ROS），并使ROS在加热和冷却过程中攻击HSP和癌细胞。这项工作揭示了热释电材料在生物医学中的应用潜力，特别是通过PEDT和PDT的PTT通过 NIR-II光刺激。

更新日期：2018-07-17

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