A new quantum dot consisting of a ZnO core wrapped in a shell of graphene ([email protected]) was synthesized and applied for the construction of an innovative electrochemical sensor for sensitive and selective determination of 6-mercaptopurine (6-MP). The sensor was fabricated based on the pencil graphite electrode (PGE) coated with a sol-gel binder reinforced with polypyrrole (PPy) based molecularly imprinted polymer (MIP), and [email protected] core-shell nanoparticles with a homogeneous environment. The procedure was carried out through a facile one-step electropolymerization stage. The synthesized quantum dots were studied by Fourier transform infrared (FT-IR) spectrometry, X-ray diffraction (XRD), Field emission scanning electron microscopy (FE-SEM) and energy dispersive X-ray (EDX). Electrochemical characterization of the sensor was performed by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). To clarify the oxidation mechanism of 6-MP, various voltammetry techniques were used. Electrochemical measurements using differential pulse voltammetry (DPV) method showed a wide linear relationship between 6-MP concentration and peak height within the range 0.01–50.0 μM and 50.0–700.0 μM with a lower detection limit (5.72 nM). The imprinted sensor was highly sensitive and was successful to detect 6-MP in real spiked samples.

合成了一个新的量子点，该量子点由包裹在石墨烯壳中的ZnO核组成（[受电子邮件保护]），并用于构建创新的电化学传感器，用于灵敏和选择性地测定6-巯基嘌呤（6-MP）。该传感器是基于涂有溶胶-凝胶粘合剂的铅笔石墨电极（PGE）制成的，该溶胶-凝胶粘合剂由聚吡咯（PPy）基分子印迹聚合物（MIP）增强，并具有均质的环境，具有[电子邮件保护]的核壳纳米粒子。该过程是通过容易的一步电聚合步骤进行的。通过傅立叶变换红外光谱（FT-IR），X射线衍射（XRD），场发射扫描电子显微镜（FE-SEM）和能量色散X射线（EDX）研究了合成的量子点。传感器的电化学特性通过循环伏安法（CV）和电化学阻抗谱（EIS）进行。为了阐明6-MP的氧化机理，使用了各种伏安技术。使用差分脉冲伏安法（DPV）进行的电化学测量显示，6-MP浓度与峰高之间的宽线性关系在0.01-50.0μM和50.0-700.0μM的范围内，检测限较低（5.72 nM）。压印传感器非常灵敏，可以成功地检测出实际加标样品中的6-MP。使用差分脉冲伏安法（DPV）进行的电化学测量显示，6-MP浓度与峰高之间的宽线性关系在0.01-50.0μM和50.0-700.0μM的范围内，检测限较低（5.72 nM）。压印传感器非常灵敏，可以成功地检测出实际加标样品中的6-MP。使用差分脉冲伏安法（DPV）进行的电化学测量显示，6-MP浓度与峰高之间的宽线性关系在0.01-50.0μM和50.0-700.0μM的范围内，检测限较低（5.72 nM）。压印传感器非常灵敏，可以成功地检测出实际加标样品中的6-MP。