Palladium/Rhodium Cooperative Catalysis for the Production of Aryl Aldehydes and Their Deuterated Analogues Using the Water–Gas Shift Reaction,Angewandte Chemie International Edition

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Palladium/Rhodium Cooperative Catalysis for the Production of Aryl Aldehydes and Their Deuterated Analogues Using the Water–Gas Shift Reaction
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-07-17 , DOI: 10.1002/anie.201806148
Malek Y S Ibrahim ₁ , Scott E Denmark ₁

Affiliation

A novel Pd/Rh dual‐metallic cooperative catalytic process has been developed to effect the reductive carbonylation of aryl halides in moderate to good yield. In this reaction, water is the hydride source, and CO serves both as the carbonyl source and the terminal reductant through the water–gas shift reaction. The catalytic generation of the Rh hydride allows for the selective formation of highly hindered aryl aldehydes that are inaccessible through previously reported reductive carbonylation protocols. Moreover, aldehydes with deuterated formyl groups can be efficiently and selectively synthesized using D₂O as a cost‐effective deuterium source without the need for presynthesizing the aldehyde.

中文翻译：

钯/铑协同催化水煤气变换反应生产芳基醛及其氘代类似物

开发了一种新型的 Pd/Rh 双金属协同催化工艺，可以以中等至良好的产率实现芳基卤化物的还原羰基化。在该反应中，水是氢化物源，CO在水煤气变换反应中既作为羰基源又作为终端还原剂。 Rh 氢化物的催化生成允许选择性形成高度受阻的芳基醛，这是通过先前报道的还原羰基化方案无法获得的。此外，使用D ₂ O作为具有成本效益的氘源，可以高效、选择性地合成具有氘代甲酰基的醛，而无需预先合成醛。

更新日期：2018-07-17

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