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Glutathione detection based on peroxidase-like activity of Co3O4–Montmorillonite nanocomposites
Sensors and Actuators B: Chemical ( IF 8.0 ) Pub Date : 2018-07-17 , DOI: 10.1016/j.snb.2018.07.091
Yan Gao , Kaili Wu , Hongyu Li , Wei Chen , Min Fu , Kang Yue , Xixi Zhu , Qingyun Liu

Co3O4 nanoparticles homogeneously anchored on montmorillonite (MMT) were synthesized via a facile hydrothermal method. Co3O4-MMT were demonstrated to possess intrinsic peroxidase- and weak oxidase-like activity, and employed as peroxidase mimics for the first time. The efficient catalytic activity of the Co3O4-MMT NCs may originate from the electron transfer among catalyst, TMB (3,3′,5,5′-tetramethylbenzidine) and H2O2. Furthermore, a sensitive colorimetric sensor for glutathione based on the peroxidase activity of Co3O4-MMT is proposed with a low detection limit of 0.088 μM. And the proposed method had been successfully applied in detecting GSH in human serum and reduced glutathione for injection solutions.



中文翻译:

基于Co 3 O 4-蒙脱土纳米复合材料过氧化物酶样活性的谷胱甘肽检测

通过简便的水热法合成了均匀锚固在蒙脱土(MMT)上的Co 3 O 4纳米粒子。Co 3 O 4 -MMT被证明具有固有的过氧化物酶和弱氧化酶样活性,并首次用作过氧化物酶模拟物。Co 3 O 4 -MMT NCs的有效催化活性可能源于催化剂,TMB(3,3',5,5'-四甲基联苯胺)和H 2 O 2之间的电子转移。此外,基于Co 3 O 4的过氧化物酶活性的谷胱甘肽敏感比色传感器-MMT建议具有0.088μM的低检测限。该方法已成功地用于人血清中谷胱甘肽和还原型谷胱甘肽的检测。

更新日期:2018-07-17
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