Amyloid β oligomer (AβO) is a promising biomarker with potential to diagnose the Alzheimer’s disease (AD). To detect the low level of AβO is highly desirable for the early diagnosis of AD. Here we describe the fabrication and sensing performance of curcumin based AβO sensor. Curcumin-Ni was electropolymerized on Ni foam substrate, and the surface resistance change of the poly(curcumin-Ni) electrode depending on AβO concentration was confirmed by electrochemical impedance spectroscopy. The impedance response of the curcumin based sensor showed a proportional relationship with the concentrations of AβO in the range from 0.001 to 5 nM. The feasibility of the sensor was verified by the detection of AβO in artificial cerebrospinal fluid. The proposed AβO sensor presents valuable information related to early diagnosis of AD.

淀粉样β寡聚物（AβO）是一种有前途的生物标志物，具有诊断阿尔茨海默氏病（AD）的潜力。对于AD的早期诊断，非常需要检测到低水平的AβO。在这里，我们描述了基于姜黄素的AβO传感器的制造和传感性能。将姜黄素-Ni电聚合在Ni泡沫基材上，并通过电化学阻抗谱确认了聚（姜黄素-Ni）电极的表面电阻随AβO浓度的变化。姜黄素基传感器的阻抗响应与AβO的浓度在0.001至5 nM之间成比例关系。该传感器的可行性通过在人工脑脊液中检测AβO进行了验证。提出的AβO传感器提供了与AD早期诊断有关的有价值的信息。