Elucidating the Impact of Molecular Structure on the 19F NMR Dynamics and MRI Performance of Fluorinated Oligomers,ACS Macro Letters

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Elucidating the Impact of Molecular Structure on the 19F NMR Dynamics and MRI Performance of Fluorinated Oligomers
ACS Macro Letters ( IF 5.1 ) Pub Date : 2018-07-16 00:00:00 , DOI: 10.1021/acsmacrolett.8b00433
Cheng Zhang , Dong Sub Kim ₁ , Jimmy Lawrence _{1,

2} , Craig J Hawker ₁ , Andrew K Whittaker

Affiliation

To understand molecular factors that impact the performance of polymeric ¹⁹F magnetic resonance imaging (MRI) agents, a series of discrete fluorinated oligoacrylates with precisely defined structure were prepared through the combination of controlled polymerization and chromatographic separation techniques. These discrete oligomers enabled thorough elucidation of the dependence of ¹⁹F NMR and MRI properties on molecular structure, for example, the chain length. Importantly, the oligomer size and dispersity strongly influence NMR dynamics (T₁ and T₂ relaxation times) and MR imaging properties with higher signal-to-noise ratio (SNR) observed for oligomers with longer chain length and shorter T₁. Our approach enables an effective pathway and thus opportunities to rationally design effective polymeric ¹⁹F MR imaging agents with optimized molecular structure and NMR relaxivity.

中文翻译：

阐明分子结构对氟化低聚物的 19F NMR 动力学和 MRI 性能的影响

为了了解影响聚合¹⁹ F 磁共振成像 (MRI) 试剂性能的分子因素，通过控制聚合和色谱分离技术的结合，制备了一系列具有精确定义的离散氟化低聚丙烯酸酯。这些离散的低聚物能够彻底阐明¹⁹ F NMR 和 MRI 特性对分子结构（例如链长）的依赖性。重要的是，低聚物的大小和分散性强烈影响 NMR 动力学（T ₁和T _{2弛豫时间）和 MR 成像特性，对于具有较长链长和较短}T的低聚物观察到更高的信噪比 (SNR)₁ . 我们的方法能够提供有效的途径，从而有机会合理设计具有优化分子结构和 NMR 弛豫度的有效聚合¹⁹ F MR 成像剂。

更新日期：2018-07-16

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