Published as part of the Special Topic Modern Coupling Approaches and their Strategic Applications in Synthesis

Abstract

Arylsulfonyl hydrazides were employed as coupling partners for the decarboxylative coupling reaction of propiolic acid derivatives. When the reaction was conducted using Pd(TFA)₂ (1.0 mol%), dppp (1.0 mol%), and Cu(OAc)₂ (2.4 equiv) in DMF at 100 °C for 0.5 hour, the desired coupled products were formed in moderate to good yields. The reaction showed good tolerance toward functional groups such as ester, ketone, cyano, nitro, chloro, and bromo groups.

Arylsulfonyl hydrazides were employed as coupling partners for the decarboxylative coupling reaction of propiolic acid derivatives. When the reaction was conducted using Pd(TFA)₂ (1.0 mol%), dppp (1.0 mol%), and Cu(OAc)₂ (2.4 equiv) in DMF at 100 °C for 0.5 hour, the desired coupled products were formed in moderate to good yields. The reaction showed good tolerance toward functional groups such as ester, ketone, cyano, nitro, chloro, and bromo groups.

中文翻译：

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钯催化的丙酸衍生物与芳磺酰肼的脱羧偶联反应

作为专题“现代耦合方法及其在综合中的战略应用”的一部分发布

抽象的

芳基磺酰肼用作丙酸衍生物的脱羧偶联反应的偶联伴侣。当使用Pd（TFA）₂（1.0 mol％），dppp（1.0 mol％）和Cu（OAc）₂（2.4当量）在DMF中于100°C进行0.5小时反应时，形成所需的偶联产物中等至良好的产量。反应显示出对官能团如酯，酮，氰基，硝基，氯和溴基的良好耐受性。

芳基磺酰肼用作丙酸衍生物的脱羧偶联反应的偶联伴侣。当使用Pd（TFA）₂（1.0 mol％），dppp（1.0 mol％）和Cu（OAc）₂（2.4当量）在DMF中于100°C进行0.5小时反应时，形成所需的偶联产物中等至良好的产量。反应显示出对官能团如酯，酮，氰基，硝基，氯和溴基的良好耐受性。