Manganese-Catalyzed ortho-C-H Amidation of Weakly Coordinating Aromatic Ketones,Organic Letters

当前位置： X-MOL 学术 › Org. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Manganese-Catalyzed ortho-C-H Amidation of Weakly Coordinating Aromatic Ketones
Organic Letters ( IF 4.9 ) Pub Date : 2018-07-16 00:00:00 , DOI: 10.1021/acs.orglett.8b01770
Xianqiang Kong ₁ , Bo Xu ₁

Affiliation

An efficient manganese-catalyzed ortho-C-H amidation of weakly coordinating aromatic ketones using the readily available sulfonyl azide as the amination reagent is developed. The key step is the ketone directed aromatic metalation using the in situ generated reactive Mn intermediate, MnMe(CO)₅. This method offers excellent chemical yields, high regioselectivities, and good functional group tolerance.

中文翻译：