The Three S's for Aptamer‐Mediated Control of DNA Nanostructure Dynamics: Shape, Self‐Complementarity, and Spatial Flexibility,ChemBioChem

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The Three S's for Aptamer‐Mediated Control of DNA Nanostructure Dynamics: Shape, Self‐Complementarity, and Spatial Flexibility
ChemBioChem ( IF 2.6 ) Pub Date : 2018-08-10 , DOI: 10.1002/cbic.201800308
Simon Chi-Chin Shiu ₁ , Andrew B. Kinghorn ₁ , Yusuke Sakai ₂ , Yee-Wai Cheung ₁ , Jonathan G. Heddle ₂ , Julian A. Tanner ₁

Affiliation

The dynamics of DNA nanostructures can be controlled by aptamers. Three considerations are highlighted to optimize aptamers for this application: shape, self‐complementarity, and spatial flexibility. There is significant potential to build better controls for nucleic‐acid‐mediated molecular recognition events through the application of aptamers for therapeutic and diagnostic purposes.