Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population,Ophthalmology

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Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population
Ophthalmology ( IF 13.1 ) Pub Date : 2018-04-30 , DOI: 10.1016/j.ophtha.2018.03.026
Matthias M. Mauschitz , Pieter W.M. Bonnemaijer , Kersten Diers , Franziska G. Rauscher , Tobias Elze , Christoph Engel , Markus Loeffler , Johanna Maria Colijn , M. Arfan Ikram , Johannes R. Vingerling , Katie M. Williams , Christopher J. Hammond , Catherine Creuzot-Garcher , Alain M. Bron , Rufino Silva , Sandrina Nunes , Cécile Delcourt , Audrey Cougnard-Grégoire , Frank G. Holz , Caroline C.W. Klaver , Monique M.B. Breteler , Robert P. Finger , Niyazi Acar , Eleftherios Anastosopoulos , Augusto Azuara-Blanco , Tos Berendschot , Tos Berendschot , Arthur Bergen , Geir Bertelsen , Christine Binquet , Alan Bird , Martin Bobak , Morten Bøgelund Larsen , Camiel Boon , Rupert Bourne , Lionel Brétillon , Rebecca Broe , Alain Bron , Gabrielle Buitendijk , Maria Luz Cachulo , Vittorio Capuano , Isabelle Carrière , Usha Chakravarthy , Michelle Chan , Petrus Chang , Johanna Colijn , Audrey Cougnard-Grégoire , Angela Cree , Catherine Creuzot-Garcher , Phillippa Cumberland , José Cunha-Vaz , Vincent Daien , Eiko De Jong , Gabor Deak , Cécile Delcourt , Marie-Noëlle Delyfer , Anneke den Hollander , Martha Dietzel , Maja Gran Erke , Pedro Faria , Claudia Farinha , Sascha Fauser , Robert Finger , Astrid Fletcher , Paul Foster , Panayiota Founti , Theo Gorgels , Jakob Grauslund , Franz Grus , Christopher Hammond , Hans-Werner Hense , Manuel Hermann , René Hoehn , Ruth Hogg , Frank Holz , Carel Hoyng , Nomdo Jansonius , Sarah Janssen , Eveline Kersten , Anthony Khawaja , Caroline Klaver , Jean-François Korobelnik , Julia Lamparter , Mélanie Le Goff , Yara Lechanteur , Terho Lehtimäki , Irene Leung , Andrew Lotery , Matthias Mauschitz , Magda Meester , Bénédicte Merle , Verena Meyer zu Westrup , Edoardo Midena , Stefania Miotto , Alireza Mirshahi , Sadek Mohan-Saïd , Michael Mueller , Alyson Muldrew , Joaquim Murta , Stefan Nickels , Sandrina Nunes , Christopher Owen , Tunde Peto , Norbert Pfeiffer , Stefano Piermarocchi , Elena Prokofyeva , Jugnoo Rahi , Olli Raitakari , Franziska Rauscher , Luisa Ribeiro , Marie-Bénédicte Rougier , Alicja Rudnicka , José Sahel , Aggeliki Salonikiou , Clarisa Sanchez , Steffen Schmitz-Valckenberg , Alexander Schuster , Cédric Schweitzer , Tatiana Segato , Jasmin Shehata , Rufino Silva , Giuliana Silvestri , Christian Simader , Eric Souied , Martynas Speckauskas , Henriet Springelkamp , Robyn Tapp , Fotis Topouzis , Elisa van Leeuwen , Virginie Verhoeven , Timo Verzijden , Therese Von Hanno , Peter Wiedemann , Katie Williams , Christian Wolfram , Jennifer Yip , Jennyfer Zerbib

Purpose

To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population.

Design

Cross-sectional meta-analysis.

Participants

A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3–82.1±4.2 years) of the European Eye Epidemiology (E3) consortium.

Methods

We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis.

Main Outcome Measures

Determinants of pRNFLT.

Results

Mean pRNFLT ranged from 86.8±21.4 μm in the Rotterdam Study I to 104.7±12.5 μm in the Rotterdam Study III. We found the following factors to be associated with reduced pRNFLT: Older age (β = –0.38 μm/year; 95% confidence interval [CI], –0.57 to –0.18), higher intraocular pressure (IOP) (β = –0.36 μm/mmHg; 95% CI, –0.56 to –0.15), visual impairment (β = –5.50 μm; 95% CI, –9.37 to –1.64), and history of systemic hypertension (β = –0.54 μm; 95% CI, –1.01 to –0.07) and stroke (β = –1.94 μm; 95% CI, –3.17 to –0.72). A suggestive, albeit nonsignificant, association was observed for dementia (β = –3.11 μm; 95% CI, –6.22 to 0.01). Higher pRNFLT was associated with more hyperopic spherical equivalent (β = 1.39 μm/diopter; 95% CI, 1.19–1.59) and smoking (β = 1.53 μm; 95% CI, 1.00–2.06 for current smokers compared with never-smokers).

Conclusions

In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT. These may be of clinical relevance, especially in glaucoma monitoring of patients with newly occurring vascular comorbidities.

中文翻译：

在欧洲眼流行病学（E3）人群中，乳头周围视网膜神经纤维层厚度的系统和眼部决定因素

目的

目的调查欧洲人群中乳头周围视网膜神经纤维层厚度（pRNFLT）的系统和眼部决定因素。

设计

横断面荟萃分析。

参加者

来自欧洲眼流行病学（E3）联盟的8个队列研究（平均年龄范围，56.9±12.3–82.1±4.2岁）中的1684名欧洲成年人。

方法

在每项研究中，我们使用多变量线性回归分析了与通过光谱域OCT测量的pRNFLT的关联，并使用随机效应荟萃分析汇总了结果。

主要观察指标

pRNFLT的决定因素。

结果

pRNFLT的平均范围从鹿特丹研究I的86.8±21.4μm到鹿特丹研究III的104.7±12.5μm。我们发现以下因素与pRNFLT降低有关：年龄较大（β= –0.38μm/年； 95％置信区间[CI]，-0.57至–0.18），眼压（IOP）较高（β= –0.36μm / mmHg; 95％CI，–0.56至–0.15），视力障碍（β= –5.50μm; 95％CI，–9.37至–1.64），和系统性高血压病史（β= –0.54μm; 95％CI， –1.01至–0.07）和行程（β= –1.94μm； 95％CI，–3.17至–0.72）。痴呆症有相关性提示（尽管不显着）（β= –3.11μm； 95％CI，–6.22至0.01）。较高的pRNFLT与远视球形当量（β= 1.39μm/屈光度； 95％CI，1.19–1.59）和吸烟（与不吸烟者相比，β= 1.53μm； 95％CI，1.00–2.06）相关。