Recent studies described several different routes that facilitate nitrogen-nitrogen bond formation in natural product biosynthesis. We report herein the identification of unprecedented machinery for hydrazine formation involved in the biosynthesis of s56-p1, a dipeptide natural product with a unique hydrazone unit. The gene cassette comprising this machinery is widespread across several bacterial phyla, highlighting the overlooked potential of bacteria to synthesize hydrazine.

中文翻译：

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在细菌中发现前所未有的肼形成机制

最近的研究描述了促进天然产物生物合成中氮-氮键形成的几种不同途径。我们在此报告鉴定了参与 s56-p1 生物合成的前所未有的肼形成机制，s56-p1 是一种具有独特腙单元的二肽天然产物。包含这种机制的基因盒广泛存在于几个细菌门中，突出了细菌合成肼的潜力被忽视。