Tuberculosis (TB) is now reckoned to be the leading infectious cause of death.¹ That multiple people die every minute from a cheaply curable disease, which has been reduced to incidence rates of below 0.01% per year in many rich countries, is plainly unacceptable. The evidence to support statements on the extent of the TB pandemic most often comes from the burden estimates released annually by the Global TB Programme at the World Health Organization (WHO).¹ The other set of global TB disease burden estimates are those of the Global Burden of Disease studies from the Institute of Health Metrics and Evaluation (IHME), which include TB as part of a large range of causes of deaths and disability.² Both sets of estimates for mortality rely on high quality vital registration systems in countries where these exist; unfortunately, in many high-TB-burden countries such systems are lacking, and differences in the modelling approaches used to leverage other data sources (and to some extent, the inclusion of additional mortality data such as verbal autopsy by IHME) lead to differences between the WHO and IHME estimates, particularly at the country level.

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评论：结核病负担估计数的利弊

结核病（TB）现在被认为是主要的传染性死亡原因。¹许多人每分钟死于一种可以廉价治愈的疾病，在许多富裕国家，这种疾病已降至每年低于0.01％的发病率，这是绝对不可接受的。支持有关结核病大流行程度声明的证据通常来自世界卫生组织（WHO）全球结核病计划每年发布的负担估算。¹另一组全球结核病疾病负担估算值是卫生计量与评估研究所（IHME）进行的全球疾病负担研究的估算值，其中结核病是各种死亡和致残原因的一部分。^2个两组死亡率估计都依赖于存在这些国家的高质量生命登记系统；不幸的是，在许多结核病高负担的国家中，缺乏这样的系统，并且用于利用其他数据源的建模方法也存在差异（并且在一定程度上包括了额外的死亡率数据，例如IHME的口头尸检）导致了两者之间的差异。 WHO和IHME的估算，尤其是在国家一级。